W2-lecture 2: Infectious particles Flashcards

1
Q

T or F : viruses are considered living entities.

A

False, viruses rely on the host cell for energy, metabolic intermediates, and protein synthesis, and so they are obligate intracellular parasites

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2
Q

What are the host cells of viruses

A

all the group of cellular organisms (archaea, bacteria and eukaryotes)

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3
Q

What is the name of the inert infectious particle

A

virion

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4
Q

What is the general structure of the virus?

A

nucleic acid (ARN + ADN) + a protein coat

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5
Q

T or F : There is two types nucleic acid found in the virion of any given virus

A

false

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6
Q

What are the three shapes of virus ?

A
  1. helical virus 2. polyhedral virus 3. complex virus
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7
Q

T or F : every virion contains an enveloppe

A

False, the bacterial viruses are naked while the animal viruses contain an envelope.

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8
Q

T or F : in some cases, the virus can come with ribosomes and some building blocks and energy.

A

false, In all cases, the host cells supply the building blocks (nucleic acids, amino acids), the machinery (ribosomes) and the energy required to produce new virus particles.

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9
Q

What are the protein subunits that makes up the capsid?

A

the capsomeres

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10
Q

What is the most common sape of the polyhedral shaped virus

A

The icosahedron

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11
Q

What is a capsid?

A

it is a protein coat around the nucleic acid of the virus. It is made of capsomere (protein). The capsid and the nucleic acid is what makes the nucleocapsid

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12
Q

What determine the shape of the virus?

A

the nature of the capsomere.

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13
Q

What are the most complicated viruses in term of structure?

A

The bacteriophages (complex viruses)

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14
Q

T or F : the bacteriophages T4 can’t infect the gram negative bacteria.

A

False, because they recognize the LPS layer that is only found in gram negative bacteria. So, they can’t infect gram positive bacteria.

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15
Q

T or F : The virion interacts with receptors on the cell wall of the host. If there is not that specific receptor, the virus can’t attach and infect the cell.

A

T

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16
Q

What are the receptor of the bacteriophage T4?

A

They LPS membrane

17
Q

What are the two pathways of infections

A

Lysogenic pathway and lytic pathway

18
Q

What happens in the lytic pathway of infection

A

In a lytic infection, the virus redirects the host cell’s metabolism from growth to support virus replication and the assembly of new virions.

19
Q

What happens during the lysogenic pathway of infection?

A

lysogenic infection; in this case, the host cell is not destroyed but is genetically altered because the viral genome becomes part of the host genome (lysogeny).

20
Q

What is a prophage?

A

The viral genome that has been incorporated into the host genome and is not expressed because of phage encoded repressor proteins.

21
Q

What is the method to look at viruses on agar plates

A

The plaque assay is used. The viruses are mixed with a permisive host and can be seen has plaques (lyse of cells) on the agar after incubation.

22
Q

What are viroids

A

Viroids are closed circles of single-stranded RNA containing 240-380

nucleotides.

23
Q

What is the cause of cadang cadang disease or potato spindle tuber?

A

viroids

24
Q

What are prions?

A

one prion (protein : PrPSc) that induces the wrong folding of normal prions in neurons. (PrPC) leading to accumulation.

25
Q

Zika virus is an example of ____ shaped virus

A

polyhedral

26
Q

Ebola is an example of ___shaped virus

A

helical

27
Q
A