Genetics of inflammation

Question 1

What are the types of genetic autoimmune disease

Answer 1

Polygenic autoinflammatory diseases

Mixed pattern diseases

Classic polygenic autoimmune diseases

Question 2

Give examples of a polygenic autoinflammatory diseases

Answer 2

Crohn’s

Ulcerative colitis

Question 3

Give examples of mixed pattern diseases

Answer 3

Psoriasis

psoriatic arthiritis

Question 4

Give examples of classic polygenic autoimmune diseases

Answer 4

Systemic lupus

Erythematosus

Question 5

What are the types of inflammatory bowel disease and what is the difference between them

Answer 5

Ulcerative colitis (inflammation and ulcers in mucosa of the colon only)

Crohn’s Disease (inflammation of all layers of GI tract)

Question 6

What are the 4 causes of inflammatory bowel disease?

Answer 6

Persistent infection
Defective mucosal integrity
Dysbiosis (decrease of health bacteria)
Disregulated immune response