1.14 Purine nucleotides

Question 1

Give the steps of Glucose → Inosine monophosphate

Answer 1

1. Glucose
2. Glucose-6-phosphate
3. Ribose-5-phosphate
4. PRPP
5. 5-phosphoribosyl-amine
6. Inosine monophosphate

Question 2

Give the steps of Inosine monophosphate → Guanosine Triphosphate

Answer 2

1. Inosine monophosphate
2. Xanthine monophosphate
3. Guanosine monophosphate
4. GDP
5. GTP

Question 3

Give the steps of Inosine monophosphate → Adenosine Triphosphate

Answer 3

1. Inosine monophosphate
2. Adenosuccinate
3. Adenosine monophosphate
4. ADP
5. ATP

Question 4

Draw the pathway of Glucose → Inosine monophosphate

Answer 4

Question 5

Draw the pathway of Inosine monophosphate → GTP

Answer 5

Question 6

Draw the pathway of Inosine monophosphate → ATP

Answer 6

Question 7

Give the regulation of purine synthesis

Answer 7

Question 8

Give the energy balance of purine synthesis

Answer 8

-8 ATP

Question 9

Give the pathway of GMP degredation

Answer 9

Question 10

Give the pathway of AMP degredation

Answer 10

Question 11

Draw the resynthesis of purine nucleotides

Answer 11

Question 12

Draw the synthesis of deoxyribonucleotides

Answer 12