1.15 Synthesis and degradation of pyrimidine nucleotides

Question 1

Give the steps of pyrimidine synthesis

Answer 1

1. Bicarbonate
2. Carbamoyl-phosphate
3. N-Carbamoyl-aspartate
4. Dihydro-orotate
5. Orotate
6. Orotidylate
7. UMP
8. UDP
9. UTP
10. CTP

Question 2

Draw the Pyrimidine synthesis pathway

Answer 2

Question 3

Give the steps of pyrimidine degradation

Answer 3

1. CMP
2. UMP
3. Uridine
4. Uracil
5. Dihydrouracil
6. Ureido-propionate
7. β-alanine

Question 4

Draw the pathway of pyrimidine degradation

Answer 4