8. protein localisation and modification Flashcards
(7 cards)
1
Q
how are proteins localised
A
- gated transport
- transmembrane transport
- vesicular transport
2
Q
default protein location
A
cytosol
3
Q
transmembrane transport steps
A
- a sorting signal targets proteins to membranes
- a translocon provides an aqueous channel for translocation
4
Q
stages of protein translocation into the ER
A
- recognition of a targeting signal
- binding to the ER receptor
- translocation in a unidirectional channel
energy dependent (GTP/G proteins)
5
Q
disorders of glycosylation
A
cause over 200 human genetic diseases
6
Q
N-glycosylated protein function
A
contributes to
- protein folding
- disulfide bond formation
- protein stability
- protein function
7
Q
N-glycosylation in CFTR
A
required for cell surface expression
