8. Sarkoidose Flashcards by Ian Paglione

Q

(Sarkoidose)

Eponym

A

Morbus Boeck

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Q

(Sarkoidose)

Epidemiologie: Häufigkeitsgipfel

A

20-40 Lj.

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Q

(Sarkoidose)

Pathophysiologie

A

Störung der T-Lymphozyten-Funktion

(Th1-gewichtete T-Helfer-Antwort)

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Q

(Sarkoidose)

Prognose

A

hohe Spontanremissionsraten

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Q

(Sarkoidose)

Komplikationen (2)

A

pulmonale
extrapulmonale

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Q

(Sarkoidose)

pulmonale komplikationen (2)

A

Bronchiektasen
Lungenfibrose

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Q

(Sarkoidose)

extrapulmonale Komplikation

A

Niereninsuffizienz

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Q

(Sarkoidose)

Symptome (2)

A

pulmonale
extrapulmonale

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Q

(Sarkoidose)

pulmonale Symptome (3)

A

Dyspnoe
Husten
thorakale Schmerzen

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Q

(Sarkoidose)

extrapulmonale Symptome: Einteilung (2)

A

akute
chronische

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Q

(Sarkoidose)

akute extrapulmonale Symptome

A

Löfgren-Syndrom

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Q

(Sarkoidose)

chronische extrapulmonale Symptome

A

Heerfordt-Syndrom

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Q

(Sarkoidose)

Löfgren-Syndrom (3)

A

Trias

Polyarthritis
Erythema nodosum
bihiläre Lymphadenopathie

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Q

(Sarkoidose)

Polyarthritis: Hauptlokalisation

A

Sprunggelenk

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Q

(Sarkoidose)

Erythema nodosum: Hauptlokalisation

A

Streckseiten der Unterschenkel

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Q

(Sarkoidose)

Heerfordt-Syndrom (3)

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A

Trias

Uveitis
Parotitis
Fazialisparese

Q

(Sarkoidose)

Laboruntersuchung

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A

Entzündungsparameter

Q

(Sarkoidose)

Bildgebung der Wahl

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A

Röntgen-Thorax

Q

(Sarkoidose)

Röntgen-Thorax: Zweck

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A

Stadieneinteilung der chronischen Sarkoidose

Q

(Sarkoidose)

Stadieneinteilung der chronischen-

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A

0-IV

Q

(Sarkoidose)

Stadium 0

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A

Normalbefund

Q

(Sarkoidose)

Stadium I

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A

bihiläre Lymphadenopathie

Q

(Sarkoidose)

Stadium II

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A

bihiläre Lymphadenopathie mit Lungenbefall

Q

(Sarkoidose)

Stadium III

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A

Lungenbefall ohne bihiläre Lymphadenopathie

(Sarkoidose) Stadium IV

Lungenfibrose

(Sarkoidose) Bildgebung der 2. Wahl

CT-Thorax

(Sarkoidose) Goldstandard

Bronchoskopie mit BAL und transbronchialer Biopsie

(Sarkoidose) BAL

bronchoalveoläre Lavage

(Sarkoidose) BAL: Befund

↑ CD4/CD8 Quotient (oft > 5)

(Sarkoidose) transbronchiale Biopsie: Befunde (3)

- nicht-verkäsende Granulome - Langhans-Riesenzellen - Schaumann-Körperchen

(Sarkoidose) Aktivitätsparameter und Therapiekontrolle (2)

- ACE - Spirometrie

(Sarkoidose) Therapieschema (3)

1. NSAR 2. Glucocorticoide 3. Immunsuppressiva