UWORLD - GI/Renal Path and Pharm

Question 1

Slow and incomplete gallbladder emptying will lead to?

Answer 1

Biliary sludge

Question 2

Alcohol-induced hepatic statosis - get fatty change. Why?

Answer 2

Decreased fatty acid oxidation

Question 3

Alcoholic cirrhosis. Antiandrogen effects lead to?

Answer 3

Gynecomastia, tesicular atrophy, decreased body hair, and spider angiomata

Question 4

Shigella invades these cells?

Answer 4

Antigen-sampling M-cells

Question 5

Asymptomatic liver cysts that can cause anaphylaxis when broken?

Answer 5

Echinococcus granulosus.

Question 6

Avoiding gallstones re: Cholesterol, Bile acids, Phosphatidylcholine?

Answer 6

Keep cholesterol low, bile acids high, and phosphatidylcholine high.

Question 7

Hepatic abscess. Organism?

Answer 7

S aureus

Question 8

Fibrinoid necrosis seen where?

Answer 8

Blood vessels from IC deposits

Question 9

Ballooning degeneration?

Answer 9

Acute hepatitis

Question 10

Granulomatous bile duct obstruction and lymphocytic infiltrate?

Answer 10

Primary biliary cirrhosis or Graft vs Host

Question 11

igG4 antibodies to PPLA2 receptor?

Answer 11

Membranous nephropathy

Question 12

Moldy gain cause what cancer?

Answer 12

Aflatoxin. Hepatocellular CA

Question 13

Iron absorbed where?

Answer 13

Jejunum

Question 14

Pt with CHF. What diuretic will increase survival? Why?

Answer 14

Spirolactone due inhibition of ALDO and decreased ventricula remodeling.

Question 15

Liver metabolizes what type of drugs?

Answer 15

Those with high lipophilicity

Question 16

Eso varicies, splenomegaly, but no abnormalities on liver biopsy?

Answer 16

Portal vein thrombosis

Question 17

Calcification of gallbladder increase risk of?

Answer 17

GB cancer

Question 18

Why gallstones in Crohn’s?

Answer 18

terminal ileum cant resorb bile acids. Bile acids prevent cholesterol stones. Increased chance of stones/

Question 19

Mech of brown gallstones?

Answer 19

Infection of biliary tract releases B-glucuronidase -> Stones