Theme 4 - Introduction to immunity Flashcards

1
Q

what are the two major health threats in high income countries?

A

healthcare associated infections and antibiotic resistance

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2
Q

name three causative agents of healthcare associated infections

A

staphylococcus aureus, enterococcus and clostridium dificle

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3
Q

name three syndromes that can results from healthcare associated infections

A

nosocomial pneumonia, wound infection, device/implant related infection

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4
Q

what bacteria is involved in antibiotic resistance?

A

gram negative bacteria

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5
Q

what was the causative organism of the Black Death?

A

yerssina pestis

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6
Q

what is the causative organism of TB?

A

mycobacterium tuberculosis

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7
Q

what did Robert koch do?

A

developed the concept of infectious diseases, discovered causes of TB and anthrax

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8
Q

how can you prove a micro-organism causes a disease?

A

isolate from organism, culture, implant into another organism (causes disease) - if it can be re isolated it caused the disease

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9
Q

what are examples of classical bacteria?

A

staph aureus and eserischa coli

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10
Q

which bacteria are cell wall deficient and therefore live inside our cells?

A

mycoplasma and chlamydiae (pneumonia and UG infections)

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11
Q

what type of bacteria causes syphilis?

A

treponema pallidum (spirochete)

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12
Q

what do viruses consist of?

A

nucleic acid in a protein coat +/- a lipid capsule

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13
Q

examples of fungal pathogens

A

yeasts and moulds

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14
Q

what is the structure of yeast and how do they reproduce?

A

they are unicellular and reproduce by budding

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15
Q

what is the structure of moulds and how do they reproduce?

A

they are multicellular and reproduce by shedding spores

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16
Q

example of a mould

A

aspergillus fumigatus

17
Q

what is a protozoa?

A

a unicellular eukaryote

18
Q

what type of diseases to protazoa cause?

A

tropical and zoonotic

19
Q

give examples of two diseases caused by protazoa

A

malaria and giardiasis

20
Q

give an example of an infection caused by a helminth

A

African eyeworm

21
Q

how many deaths worldwide are caused by infection?

A

1 in 3

22
Q

what is an antigen?

A

a substance that triggers an immune response in the body

23
Q

what is immunological tolerance?

A

a state of immunological non reactivity to an antigen

24
Q

give three examples of antigens that the immune system to tolerant to

A

our own proteins (self antigens), environmental antigens (pollen/food), commensals

25
Q

what is the result of a breakdown in immune tolerance?

A

autoimmunity and allergy