L15- Cancer

Question 1

cancer is described as a

Answer 1

multi-step model

Question 2

cancer occurs due to an

Answer 2

accumulation of mutations, which occur over time

Question 3

replication stress

Answer 3

stimulates carcinogenesis

Question 4

tumours have

Answer 4

have intra tumour heterogeneity

Question 5

intra tumour heterogeneity

Answer 5

a tumour is not one clone but lots of different cell types called ‘sub clones’.

Question 6

mutations in DNA repair factors are

Answer 6

comnon in cancers

Question 7

heterogeneity of tumours promtoes

Answer 7

tumour evolution

Question 8

heterogenous tumours and chemotherapy

Answer 8

important subclones are treated differently

Question 9

in heterogenous tumours, chemotherapy can cause

Answer 9

• differential sensitivity
• chemotherpay induced mutagenesis

Question 10

differential sensitivity

Answer 10

alll subclones accept one are destroyed

Question 11

chemotherapy induced mutagenesis

Answer 11

chemotherapy causes new subclone to form

Question 12

synthetic lethality

Answer 12

When a combination of deficiencies in the expression of two or more genes leads to cell death, whereas a deficiency in only one of these genes does not.