GI System- MoA

Question 1

Antacids

Antacids + alginates

Answer 1

Gastric acid neutralisation

Question 2

H2-receptor antagonists

Answer 2

Blockade of gastric H2 histamine receptors

Question 3

PPIs

Answer 3

Blockade of stomach acid transporters

Question 4

Pancreatic enzymes

Answer 4

Restoration of pancreatic enzymes

Question 5

Bulk laxatives

Answer 5

Water absorption in intestinal lumen to bulk stools

Question 6

Faecal softener

Answer 6

Stimulates water & electrolyte secretion into intestinal lumen
Lower surface tension - allowing water and fat to enter stool, softening stool consistency & increasing bulk to aid transit

Question 7

Osmotic laxatives

Answer 7

Water retention in intestinal lumen

Question 8

Stimulant laxatives

Answer 8

Increase intestinal motility

Question 9

Opioid anti-motility agents

Answer 9

Agonist for u-opioid receptors in myenteric plexus. Blocks intestinal muscarinic receptors

Question 10

Paracetamol antidote

Answer 10

Restoring & maintaining hepatic intracellular glutathione required for paracetamol detoxification

Question 11

Benzodiazepine (for alcohol withdrawal)

Answer 11

Potentiation of GABAA receptors

Question 12

Non-benzodiazepine hypnotic (for alcohol withdrawal)

Answer 12

GABA mimetic - GABAA receptor agonist

Question 13

Substance abuse treatment agent (for alcohol rehabilitation)

Answer 13

GABA mimetic - GABAA receptor agonist; possible NMDA receptor antagonist