Neurocritical care and drugs Flashcards
1
Q
How does labetalol work?
A
selective alpha blocker, beta non-selective
2
Q
What is thiopental?
A
short acting barbiturate
3
Q
How do NSAIDS work?
A
Inhibiting COX - cyclooxygenase - Which participates in the synthesis of prostaglandins and thromboxanes
4
Q
What is different about aspirin compared to other NSAIDs in its interaction with cyclooxygenase?
A
aspirin binds irreversibly - which is why you have to wait 8-10 days for it’s anti-platelet function to wear off
5
Q
What is the Cockroft gault equation?
A
how to work out creatinine clearance
[140-age] x ideal weight / 72 x serum creatinine (x.85 in females)
6
Q
How does tramadol work?
A
Weak opioid - binds to mu-receptors and inhibits re-uptake centrally of norad and serotonin
7
Q
What is tryptophan?
A
serotonin pre-cursor
