Phosphodiesterase-4 inhibitors Flashcards
1
Q
Mechanism of action
A
Inhibits PDE4 leading to increased cAMP
2
Q
Roflumilast brand name
A
Daliresp
3
Q
Roflumilast dosage form
A
Tablet
4
Q
Roflumilast age range
A
12 and up
5
Q
Roflumilast AE and Clinical Pearls
A
AE: HA, weight loss, diarrhea, nausea
Monitoring: liver function test, weight
DI: CYP3A4 (major), CYP1A2 (minor)
CI: Child-pugh class B or C
