Short-Acting Anticholinergics

Question 1

Mechanism of Action

Answer 1

Competitively inhibit cholinergic receptors in bronchial smooth muscle to decrease cGMP to cause bronchodilation

Question 2

Ipratropium HFA brand name

Answer 2

Atrovent

Question 3

Ipratropium HFA dosage form

Answer 3

MDI

Question 4

Ipratropium HFA age range

Answer 4

All ages

Question 5

Ipratropium HFA AE and Clinical Pearls

Answer 5

AE: dry mouth, urinary retention, infection, sinusitis, bronchitis
Used in combo with albuterol for asthma exacerbation treatment
May mix in same nebulizer with albuterol
Should not be used as first-line therapy; should be added to SABA therapy for severe exacerbations

Question 6

Ipratropium dosage form

Answer 6

nebulizer solution

Question 7

Ipratropium age range

Answer 7

all ages

Question 8

Ipratropium/Albuterol inhaler brand name

Answer 8

Combivent respimat

Question 9

Ipratropium/Albuterol inhaler dosage form

Answer 9

MDI

Question 10

Ipratropium/Albuterol inhaler strength

Answer 10

20 mcg/100 mcg/ inhalation

Question 11

Ipratropium/Albuterol inhaler age range

Answer 11

all ages

Question 12

Ipratropium/Albuterol inhaler dosings

Answer 12

1 inhalation Q6H

Exacerbation dosing: 8 inhalations Q20 minutes PRN up to 3 hours

Question 13

Ipratropium/Albuterol inhaler AE and Clinical Pearls

Answer 13

AE: see individual products

Question 14

Ipratropium/Albuterol nebulizer brand name

Answer 14

DuoNeb

Question 15

Ipratropium/Albuterol nebulizer dosage form

Answer 15

Nebulizer solution

Question 16

Ipratropium/Albuterol nebulizer strength

Answer 16

0.5 mg/2.5 mg per 3 mL vial

Question 17

Ipratropium/Albuterol nebulizer age range

Answer 17

all ages

Question 18

Ipratropium/Albuterol nebulizer dosing

Answer 18

3 mL Q20 minutes x 3 doses, then PRN (off-label)

Question 19

Ipratropium/Albuterol nebulizer AE and Clinical Pearls

Answer 19

May be used for up to 3 hours in initial management of severe exacerbations