Gastro - symptoms + signs Flashcards

1
Q

Boerhaave’s syndrome symptoms + signs

A
  • Chest pain (retrosternal, epigastric)
  • Pneumomediastinum
  • Shock (dyspnoea, tachypnoea, low BP, narrow pulse pressure)
  • Subcutaneous emphysema
  • L sided pleural effusion

Presents with chest pain, pt likely in shock (hypotension)
Mackler’s triad – classical presentation
• Chest pain
• Vomiting
• SC emphysema (air trapped in SC tissues)

Hours to days later
•	Pleural effusions (L side)
\+/-
Pneumothorax
Widened mediastinum
SC emphysema 
Hamman's sign - crunching sound upon auscultation of the heart due to pneumomediastinum
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2
Q

Haemorrhoids symptoms

A
  • Bleeding (most common symptom)
  • Itching
  • Anal lumps
  • Prolapsing tissue
  • Pain
  • Tenesmus
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3
Q

Acute Appendicitis symptoms

A
  • Abdominal pain + vomiting
    Poorly localised at the start, then localises in the RIF
  • Diminished BS
  • Rovsing’s sign - palpation of the LIF results in greater pain in the RIF than the L
  • McBurney’s sign - Percussion tenderness maximal over a point approximately 2/3 of the distance from the umbilicus laterally towards the ASIS
  • Obturator sign/Cope’s sign - pain when passively internally rotating the hip
  • Psoas sign - pain when passively extending the hip (represents a retrocaecal appendix)
  • Dunphy’s sign - aggravation of abdominal pain by coughing
  • PR - R sided tenderness
  • Signs of peritonitis if perforation is present
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4
Q

What do the different appendicitis signs mean?

A
  • Rovsing’s sign - LIF palpation results in RIF pain
  • McBurney’s/Aaron’s sign sign - percussion tenderness maximal at a point approx 2/3 away from umblilicus towards ASIS
  • Obturator sign/Cope’s sign- pain when passively internally rotating the hip
  • Psoas sign - pain when passively extending the hip sign of a retrocecal appendix
  • Dunphy’s sign - aggravation of abdominal pain by coughing
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5
Q

Perforated appendix symptoms

A
  • Fever
  • Flushed
  • Tachycardic
  • Peritonitis
  • Diminished BS
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6
Q

Bowel / intestnal obstruction clinical features

A
  • Absolute constipation + paralytic ileus – no flatus
  • Diffuse Colicky abdominal pain
  • Distended abdomen, tympany due to air-filled stomach
  • N+V (esp in small bowel obstruction)
  • Change in bowel habits – Failure to pass bowel movements
  • In low level obstruction there may be a hx of progressive constipation or change in bowel habit
  • Severe pain + tenderness - ischaemia or perforation
  • High-pitched bowel sounds - obstruction
  • Silent bowel sounds - ileus or perforation
  • Abdominal mass
  • Dehydration
  • Empty rectum on DRE – proximal obstruction
  • Soft stools on DRE – partial obstruction
  • Acute abdomen with peritonism, tachycardia, fever - ?perforation
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7
Q

L-sided vs R-sided colon cancer

A

L sided - presents earlier, less advanced disease on presentation

  • Early change in bowel habits
  • Colicky abdominal pain
  • Bowel obstruction
  • Rectal bleeding
  • Tenesmus
  • Mass in LIF

R sided - presents later, more advanced disease at presentation

  • Anaemia
  • Weight loss
  • Occult bleeding (bleeding not visible to the patient or the physician but it can cause iron deficiency anaemia)
  • Mass in RIF
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8
Q

Volvulus symptoms

A
  • Severe colicky abdominal pain + distension
  • Absolute constipation - intestinal obstruction
  • Hx of transient attacks in which spontaneous reduction of the volvulus has occured - relieved by passage of large amount of stool +/or flatus
  • Vomiting - occurs late when destruction might be severe, leads to metabolic acidosis
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9
Q

Colonic perforation symptoms + signs

A
  • Peritonitis
  • Fever
  • Tachycardia
  • Hypotension
  • Signs of dehydration
  • Oliguria
  • Shock
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10
Q

Gallstones + biliary colic symptoms + signs

A
- Biliary colic
   Constant pain
   RUQ
   May radiate around to the back in the interscapular region    
Increases in intensity + lasts for hours
- N + V
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11
Q

Cholecystitis symptoms + signs

A
  • Main difference from biliary colic is the inflammatory component
    Local peritonism
    Fever
    Raised WCC
  • Intense, constant RUQ pain radiating to back, R shoulder, chest
  • Distended, tender, palpable gallbladder
  • Murphy’s sign
  • Boas Sign- pain radiates scapula
  • N+V
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12
Q

Acute cholangitis signs + symptoms

A

Charcot’s triad

  • RUQ pain
  • Fever
  • Jaundice

Reynold’s pentad also includes

  • Hypotension
  • Altered mental status
  • Pruritus
  • Pale stools - deficient bile secretion to the small intestine
  • Leukocytosis
  • Abnormal LFTs
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13
Q

Mallory Weiss tear signs + symptoms

A
  • Haematemesis
  • Dizziness
  • Postural hypotension
  • Melaena
  • Rockall score <3
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14
Q

Toxic megacolon symptoms and signs

A
  • Large bowel dilation >6cm
  • Abdominal tenderness
  • Abdominal distention
  • Tachycardia
  • Anaemia
  • Fever
  • Pt acutely unwell

NON-OBSTRUCTIVE dilation of the bowel
Systemic upset

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15
Q

Cirrhosis symptoms + signs

A
  • Ascites
  • Peripheral oedema
  • Jaundice + pruritus
  • Haematemesis + melaena
- Hand + nail features
   Leukonychia
   Palmar erythmea
   Spider naevi
   Bruising
   Clubbing
   Dupuytren's contracture
- Facial features
   Telangiectasia
   Scleral icterus
   Spider naevi
   Red tongue
   Xanthelasma 
  • Abdominal features
    Caput medusae
    Hepatosplenomegaly
    Distension
  • Gynaecomastia
  • Loss of secondary sexual hair/testicular atrophy in men
  • Muscle wasting
  • Easy bruising
  • Signs of portal HTN
    Ascites
    Caput medusae
    Enlarged spleen
  • Signs of hepatic encephalopathy
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16
Q

Complications of cirrhosis

A

Related to the development of liver insufficiency + portal HTN
• Anaemia, thrombocytopenia, coagulopathy
Anaemia – folate deficiency, haemolysis, hypersplenism
Thrombocytopenia – 2o to hypersplenism + low levels of thrombopoietin
Coagulopathy - decreased hepatic production of coagulation factors, cholestasis causes decreased vitamin K absorption, decreased hepatic production of factors 2, 7, 9, 10

• Oesophageal varices – upper GI endoscopy
o Portal HTN
o Prophylactic abx at presentation
o Endoscopic variceal band ligation for primary prevention of bleeding

• Ascites – abdo US
o TIPS for people with cirrhosis who have refractory ascites
o May be associated with spontaneous bacterial peritonitis SPB = ascites neutrophils > 250 cells/mm3
o Spread of bacteria across the gut wall/haematogenus bacterial spread
o E. coli

  • Portal HTN (causes distortion of the hepatic vasculature + can lead to increased intrahepatic resistance)
  • Liver failure
  • Hepatocellular carcinoma – abdo US/CT/MRI
  • Jaundice
  • Portosystemic encephalopathy
  • AKI
  • Hepatopulmonary syndromes – pulmonary arteriolar vasodilation, shunting, hypoxaemia
  • Cirrhotic cardiomyopathy – cardiac hypertrophy + blunted stress response of the heart
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17
Q

Wernicke’s encephalopathy triad

A

CAN

  • Confusion
  • Ataxia
  • Nystagmus (Opthalmoplegia)

(due to vitamin B1 deficiency)

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18
Q

Grade 0 hepatic encephalopathy symptoms + signs

A

Normal mental status

Minimal changes in memory, concentration, intellectual function, co-ordination

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19
Q

Grade I hepatic encephalopathy symptoms + signs

A
  • Change in behaviour
  • Mild confusion
  • Slurred speech
  • Euphoria or depression
  • Decreased attention
  • Slowing ability to perform mental tasks
  • Disordered sleep
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20
Q

Grade 2 hepatic encephalopathy symptoms + signs

A
  • Obvious personalty changes
  • Inappropriate behaviour
  • Lethargy
  • Moderate confusion
  • Drowsiness
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21
Q

Grade 3 hepatic encephalopathy symptoms + signs

A
  • Marked cofusion (stupor)
  • Unable to perform mental tasks
  • Disorientation to time and place
  • Occasional fits with rage
  • Incoherent speech
  • Sleeping but arousable
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22
Q

Grade 4 hepatic encephalopathy symptoms + signs

A
  • Coma- +/- response to pain
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23
Q

N+V+D approx 1-6h following ingestion of contaminated dairy products or cold meat

Organism and treatment?

A

Staph aureus

Produces heat-stable endotoxin
Supportive treatment

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24
Q

V+ later D following consumption of reheated rice

Organism?

A

Bacillus cereus

D typically occurs 8-16h following vomiting

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25
Q

Abdominal pain, D, rectal bleeding following consumption of contaminated poultry

Organism and treatment?

A

Campylobacter

Symptoms last for approx 1-2 weeks

Erythromycin

26
Q

Bloody diarrhoea witihin 1-2days of consuming contaminated meat
Organism and treatment?

A

E.coli

Use of abx contraindicated - may lead to toxin production

27
Q

D, abdominal pain, bloody stools following contact with infected animals or ice cream

Organism and treatment?

A

Yersinia enterocolitica

Dx by serology
Supportive treatment

28
Q

Pharyngeal pouch symptoms and signs

Cause
Epidemiology

A
  • Dysphagia
  • Halitosis
  • Food getting stuck in throat
  • Regurgitation
  • Chronic cough
  • Nocturnal cough
  • Aspiration
  • Weight loss

Cause - structural or functional abnormality of the cricpharyngeous

Epidemiology - most common in elderly patients

29
Q

Colicky postprandial abdominal pain - what does it indicate

A

Chronic mesenteric/intestinal ischaemia

30
Q

Peritonitis triad

A

Motionless patient
Tenderness and guarding on abdominal palpation
Absent BS

31
Q

Describe the pain in acute pancreatitis

+ other symptoms+ signs

A

Sudden onset mid-epigastric/LUQ pain
Radiates to the back
Relieved by sitting forwards

• Hypovolemia
o Decreased skin turgor, dry mucous membranes, hypotension, sweating
o Tachycardic + tachypnoeic patient in more severe cases

• Increased serum [amylase]/[lipase] supports but is not pathognomonic

  • Grey-Turner’s sign – indicates haemorrhagic pancreatitis
  • Cullen’s sign – indicates haemorrhagic pancreatitis
32
Q

Hallmark features of chronic pancreatitis

A
Decreased pancreatic exocrine function 
Malabsorption
Diabetes
Pancreatic calcifications
loss of endocrine (diabetes) + exocrine (e.g. lipase, leading to malabsorption) secretion
33
Q

Describe pain in chronic pancreatitis

+ other symptoms+ signs

A

Dull epigastric abdominal pain
Radiates to the back
Relieved by sitting forwards
Worse approx 30 mins after a meal

  • Steatorrhea – due to injury, atrophy, loss of pancreatic exocrine tissue
  • Jaundice – consider pancreatic cancer if pt presents with painless Jaundice
  • N+V – non-specific

Loss of endocrine (DM) + exocrine (malabsorption) function
• DM
• Malnutrition + weight loss – fear of food due to pain, malabsorption, uncontrolled DM – consider pancreatic cancer

34
Q

Signs of peritonitis

A

Guarding
Rebound tenderness - Blumberg sign
Fever
Sinus tachycardia

35
Q

How does upper gastrointestinal bleeding present?

A

Coffee-ground vomiting (vomiting with partially digested blood)

Melaena (blood digested partly by HCl as opposed to haematochezia which is blood that hasn’t had time to be digested in the stomach)

36
Q

Extra articular manifestations of IBD

A

Joints
- Inflammatory arthritis - can be various forms (polyaritcular like RA, sacroilietis lke AS)

  • Eyes
    Anterior uveitis
    Episcleritis
    Scleritis
  • Skin
    Erythema nodosum
    Pyoderma gangrenosum
Crohns
Mouth ulcers
Oxalate renal calculi
fissures
skin tags
37
Q

Diverticulitis symptoms + signs

A

• LLQ/suprapubic abdominal pain
o Can be assosciated with a change in bowel habits
o Guarding + tenderness in LLQ
o Exacerbated by eating
o Diminished with defecation or flatus
o Generalised peritonitis if diverticulum has perforated

  • Bloating, Constipation, Rectal bleeding may occur
  • Anorexia, N+V
  • Fever + tachycardia
  • Leucocytosis
  • Urinary symptoms [pneumaturia, faecaluria, recurrent UTIs] - diverticular fistulation in the bladder
  • PR - pelvic tenderness, mass
  • Examination: tenderness, palpable mass
38
Q

Acute mesenteric ischaemia sympotms + signs

A

• Sudden onset diffuse abdominal pain
• Haematochezia/melaena
• Diarrhoea
• Abdominal bruit – indicates turbulent flow through an area of vascular narrowing
• Peritonism in later stages – rebound guarding, tenderness
o Suggests full thickness ischaemia, perforation or alternative diagnosis

Triad of

  • Diffuse abdominal pain
  • Shock signs
  • Normal examination

If the physical exam demonstrates signs of peritonitis, there is likely irreversible intestinal ischemia with bowel necrosis

39
Q

Chronic mesenteric ischaemia symptoms and signs

A
  • Weight loss – usually related to sitophobia
  • Colicky Postprandial abdominal pain (intestinal angina)
  • Haematochezia/melaena
  • Nausea, vomiting, bowel irregularity
  • Normal abdominal examination
40
Q

Signs of increased oestrogen in chronic liver disease

A
  • Palmar erythema
  • Gynaecomastia
  • Loss of secondary sexual hair
  • Testicular atrophy
41
Q

Wilson’s disease symptoms + signs

A

• Present either with
o Hepatic disease
o Movement disorder neurological disease [copper deposition in basal ganglia]

• HEPATIC features
o Acute liver failure
o Chronic hepatitis + cirrhosis
o Fulminant hepatic failure

•	BEHAVIOURAL abnormalities 
o	Loss of control of emotions
o	Depression
o	Delusions
o	Loss of memory
o	Inability to focus on tasks
o	Impulsiveness
o	Sexual disinhibition

• NEUROLOGICAL features - MOVEMENT disorder
o Asymmetrical Tremor
o Dysarthria
o Dystonia – more common in upper extremities
o Incoordination
o Ataxia, clumsiness
o Mask-like facies
o Sloppy/small handwriting
o Dysdiadochokinesia
o Normal sensation, muscle strength, reflexes

• OPHTHALMOLOGICAL features
o Kayser-Fleischer ring [copper deposition in the descemet’s membrane – membrane between endothelial layer + stroma]
o Sunflower cataracts
o Abnormal extraocular movements – exotropic strabismus
o Night blindness
o Optic neuritis
o Optic disc pallor

• Other complications
o Hepatosplenomegaly
o Renal disease – damage to proximal tubules – Fanconi syndrome
o Haemolytic anaemia – cu damages rbc

42
Q

Haemochromatosis symptoms + signs

A
  • Fatigue
  • Weakness
  • Lethargy

• Arthropathy –> Arthralgias
o Calcium pyrophosphate crystal deposition
o Pseudogout
o Chronic arthropathy

iron deposits on pituitary
• Diabetes
• Hypogonadism (impotence, loss of libido, amenorrhoea)
• Heart disease

• Skin pigmentation
o May begin as bronzing of the skin but then progress to grey or brown with slate-grey patches in the mouth

• Neurological or psychiatric symptoms – impaired memory, mood swings, irritability, depression

Liver
•	Hepatomegaly
•	Fibrosis
•	Cirrhosis
•	Hepatocellular cancer
Buzzwords
Fatigue, arthralgias
“Bronzed skin” 
“Diabetes” 
“Hepatomegaly”
MCP Arthritis
43
Q

Hiaus hernia symptoms + signs

A
  • May be asymptomatic
  • Tender abdomen
  • Heartburn
  • Regurgitation
  • Dysphagia
  • Odynophagia
  • Hoarseness
  • Asthma
  • SOB
  • Chest pain
  • Anaemia
  • Haematemesis
44
Q

Triad of hepatitis

A

Fever
Jaundice
Raised ALP, AST (in the 1000s apart from Hep B)

45
Q

Peptic ulcer disease symptoms + signs

A
  • Recurrent epigastric pain related to eating
  • Epigastric tenderness
  • Heartburn
  • Early satiety
  • N + V
  • Potential anorexia + weight loss
  • Pointing sign (patient can point to where the pain is)

duodenal more common than gastric!!
Duodenal - pain better after food, people tend to overeat and gain weight
Wakes patient at night

Gastric - pain worse after food, people tend to not eat and lose weight

46
Q

signs of metastatic abdominal cancer

A
  • Virchow’s node – Troisier’s sign

* Sister Mary Joseph node – metastatic nodule on umbilicus

47
Q

Boerhaave’s perforation symptoms + signs

A

Presents with chest pain, pt likely in shock (hypotension)
Mackler’s triad – classical presentation
• Chest pain
• Vomiting
• SC emphysema (air trapped in SC tissues)

Hours to days later
•	Pleural effusions
\+/-
Pneumothorax
Widened mediastinum
SC emphysema 

Sign
Hamman’s sign - crunching sound upon auscultation of the heart due to pneumomediastinum
CXR/CT - pneumomediastinum

48
Q

Ruptured peptic ulcer symptoms + signs

A
  • Coffee ground vomiting
  • Melaena (usually happens prior to rupture)
  • Epigastric pain
  • Dyspepsia
  • May be asymptomatic
  • Low BP
49
Q

IBS signs + symptoms

A

> 6 month history of abdominal pain
• Colicky
• Lower abdomen
• Relieved by defecation or flatus

Altered bowel frequency
• >3 bowel motions daily
• <3 motions weekly

  • Change in stool consistency
  • Passage with urgency or straining
  • Tenesmus
  • Bloating
  • Pellet like stools – buzzword!
50
Q

Coeliac disease signs + symptoms

A

• GI symptoms
o Diarrhoea
o Bloating
o Abdominal pain/discomfort, cramping, distension

• Malabsorption
o Calories: Failure to thrive, Weight loss
o Vitamins, minerals: osteoporosis, anaemia, neuropathy
o Fats: steatorrhoea

• Dermatitis herpetiformis (has nothing to do with the herpes virus)

51
Q

What is Boas’s sign

A

Shoulder tip pain resulting from diaphragmatic iritation

Can be a sign of acute cholecystitis

52
Q

Which artery does the cystic artery arise from?

A

R hepatic artery

53
Q

Which of the following biochemical markers is the most specific indicator of hepatocyte damage?

Amylase
ALP
AST
ALT
Bilirubin
A

ALT

AST is also released by RBC, cardiac tissue, brain tissue, skeletal muscle, kidney

54
Q

Features of Gilbert’s disease

A
Normal LFTs
Normal Hb levels
Serum bilirubin <100μM
No bilirubin on urine dipstick
Normal reticulocyte count - therefore no haemolysis
55
Q

Riegler’s triad

what is it a sign of

A

Small bowel obstruction
Pneumobilia (air in the biliary tree)
Ectopic gallstones seen on AXR/US/CT

sign of gallstone ileus

56
Q

Gallstone ileus happens as a result of formation of……

Commonest site of stone impaction….

A

cholecysto-duodenal fistula

ileocaecal junction

57
Q

Complications of Crohn’s

A
  • intraluminal stricture formation (string sign of Kantor)
  • Intraabdominal abscess formation
  • Fistula formation with the bladder, vagina
  • Malabsorption
  • Increased risk of bowel cancer
58
Q

Hepatitis A triad

HAV

A

Fever
Jaundice
Malaise

but usually asymptomatic

59
Q

HBV
vs
HCV

Hepatitis B
Hepatitis C

A

Hep B virus
• Most infections are asymptomatic
• Some will present with complications – cirrhosis, hepatocellular carcinoma, liver failure
• Some will also present with symptoms of cirrhosis + liver failure – ascites, hepatomegaly, jaundice, N+V, RUQ pain
• HBV – membranous + mesangiocapillary glomerulonephritis – does not cause haematuria

Hep C virus
•	Most infections are asymptomatic
•	Hepatic inflammation can lead to progressive hepatic fibrosis 
1/3 of patients experience 
•	Fatigue
•	Arthralgia
•	Jaundice
•	HCV – cryoglobulinemia-mediated glomerulonephritis – causes haematuria 
  • Chronic HCV is much more common than HBV
  • Can cause liver fibrosis - cirrhosis - HCC
60
Q

triad of haemochromatosis

A

bronze skin
hepatomegaly
DM

61
Q

Triad of acute mesenteric ischaemia

vs chronic mesenteric ischaemia

A

Acute mesenteric ischaemia
Severe abdominal pain
Normal abdominal examination
Shock

Chronic mesenteric ischaemia
Poorly localised, colicky, post-prandial pain
PR bleeding
Weight loss

62
Q

Budd-Chiari syndrome

A

Budd-Chiari syndrome = hepatic vein outflow obstruction commonly by thrombosis or malignant obstruction

Sudden onset ascites
Tender hepatomegaly
NO jaundice

Dx made by doppler scanning of the hepatic vein or venography