Antifungals

Question 1

how many main families of antifungals

Answer 1

2

Question 2

name the main families of antifungals

Answer 2

azoles and polyenes

Question 3

give an example of an azole

Answer 3

fluconazole

Question 4

fluconazole can be used to treat

Answer 4

both systemic and superficial fungal infections

Question 5

although there are other azoles why is fluconazole important

Answer 5

fluconazole has relatively smaller chance of side effects

Question 6

fluconazole resistance

Answer 6

Some resistant strains of Candida have been detected, so a susceptibility test will need to be done first before prescribing

Question 7

azoles treatment for aspergillum infection

Answer 7

posaconazole

Question 8

mode of action of fluconazole

Answer 8

inhibiting the cell wall synthesis, growth and cell adhesion- selective for fungal cytochrome P45- enzymes rather than human

Question 9

mode of action of polyenes

Answer 9

inhibit cell membrane function

Question 10

example of a polyene

Answer 10

nystatin

Question 11

nystatin is prescribed as a

Answer 11

a topical treatment for Candida infection

Question 12

why isn’t nystatin given via IV

Answer 12

can be toxic

Question 13

name a polyene given IV

Answer 13

amphotericin

Question 14

amphotericin prescribed for

Answer 14

systemic fungal infections