Development of Lymphocytes Flashcards
What 8 cell types make up the innate immune system?
β neutrophils β macrophages β monocytes β NK β dendritic cells β eosinophils β basophils
What 3 cell types make up the adaptive immune system?
β B cells
β T cells
β plasma cells
What are 2 conditions and 1 drug that can affect B cells?
β Congenital agammaglobulinaemia
β common variable immunodeficiency (CVID)
β rituximab
What are 2 conditions and 3 acquired reasons that can affect T cells?
β SCID
β DiGeorge syndrome
β HIV/chemotherapy/novel biologics
What are the 8 ways that a lymphocyte can be classified?
β Morphology β lineage β function β phenotype β specificity β type of receptor β differentiation β their products
What are the two key features of adaptive immunity?
β Specificity and memory
Describe the basic tenet of adaptive immunity?
β one cell has one specificity β one B cell has one Ig β one T cell has one TCR β selection and expansion of the clone β retention in memory of clonal progeny
How much time does the primary response take to peak?
β A couple of weeks
What is the difference between the primary and secondary response?
β it is quicker and peaks at a higher level
What precursor do B and T cells come from?
β Common lymphoid precursor
What happens to T cells after they are made from the lymphoid precursor?
β They are programmed in the thymus
β They are distributed among lymphoid organs
What is the defining feature of a lymphocyte?
β The receptor
Describe the receptor on an alpha beta T cell?
β alpha chain and a beta chain
β the top region is highly variable
What adds to the diversity of the lymphocyte receptors?
β genetic reshuffling
What are the 4 ways the immune system recognises pathogens?
β It looks like a pathogen
β their presence is associated with damage
β the pathogens have been seen before
β it is not βselfβ
What are DAMPs?
β damage associated molecular patterns
