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Step 1 - Path > Neuro-path > Flashcards

Neuro-path Flashcards

1
Q

genes in early onset alzheimer’s

A

APP (21), pesenilin-1 (14), presinilin-2 (1)

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2
Q

genes in late onset alzeimer’s

A

ApoE4

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3
Q

protective gene against alzeimer’s

A

ApoE2 (19)

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4
Q

protein in alzheimer’s plaques

A

Amyloid AB

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5
Q

protein in alzheimer’s tangles

A

tau protein

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6
Q

parkinson’s with hallucinations/dementia

A

lewy-body dementia

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7
Q

defect protein in lewy body dementia

A

a-synuclien

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8
Q

bad prion form in CJD

A

PrP(sc)

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9
Q

vitamin deficiencies that can cause dementia

A

B1/B2/B12

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10
Q

triad sx of MS

A

scanning speech, intention tremor/incontinince, nystgamus

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11
Q

common demographics for MS

A

white women in 20-30s

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12
Q

CSF findings in MS

A

IgG, oglioclonal bands

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13
Q

sx of MS

A

B-interferon, immunosuppression, natalizumab,

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14
Q

drug for MS spasticity

A

baclofen

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15
Q

infections that can precipitate GB

A

camplyobacter, CMV

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16
Q

tx for GB

A

supportive, plasmapheresis, IV immune globlulins

17
Q

GB findings

A

CSF protein with normal cell count, papilledema

18
Q

dx due to deficincu of galacrocebrosidase

A

krabbe’s sx

19
Q

causes progressive leukoencephalopathy

A

AIDS or JC virus

20
Q

focal point of most seizures

A

temporal lobe

21
Q

abortive tx for migraines

A

triptans

22
Q

prophylaxic for migranes

A

B blockers, topirmate

23
Q

port wine stains in V1 distibution, ipsilateral leptomeningeal angiomas, pheos

A

sturge-Weber

24
Q

hamatroms, ash leaf spots, MR, seizure, mitral regurg, cardiac rhabdo

A

tuberous sclerosis

25
Q

cafe-au lait spots, lisch nodules, NFs in skin, optic gliomas, pheos

A

neurofibromatosis 1 (NF1 AD)

26
Q

cavernous hemangiomas in skin, bilateral renal cell carcinomas, hemangioblastomas in retina, brain stem, cerebellum, pheos

A

Von Hippel lindau (VHL AD)

27
Q

most common adult primary tumor

A

glioblastoma

28
Q

most aggressive adult brain tumor

A

glioblastoma

29
Q

glioblastomas stain for

A

GFAP

30
Q

common benign adult brain tumor

A

meningioma

31
Q

histology of meningioma

A

spindle cells in whorled pattern, psomoma bodies

32
Q

schwannomas localize to

A

CNVIII (commonly at cerebropontine angle)

33
Q

“fried egg” looking brain tumors

A

oligodendroma

34
Q

childhood brain tumors that can cause hydrocephalus

A

ependyoma

35
Q

most malignant childhood tumor

A

medulloblastoma

36
Q

benign posterior fossa childhood brain tumor

A

pilocytic astrocytoma

37
Q

perivascular pseudorosettes

A

epedyoma

38
Q

nearly instantly fatal herniation

A

tonsillar herniation

Step 1 - Path (12 decks)

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