9

Question 1

what can FFP can group B have

Answer 1

B or AB

Question 2

presentation chronic myeloid leukaemia

Answer 2

• anaemia
• splenomegaly
• weight loss
• hyperleukostasis
• gout

Question 3

what can anti-D cause when RhD negative person exposed to RhD positive person

Answer 3

• transfusion reactions

- haemolytic disease of newborn

Question 4

universal recipient

Answer 4

AB

Question 5

universal donor

Answer 5

O

Question 6

effects of paraprotein

Answer 6

• renal failure
• hyperviscosity
• bleeding (retinal/ oral/ nasal/ cutaneous)
• hypogammaglobinaemia
• tendency to infection
• amyloidosis
• nephrotic syndrome
• cardiac failure

Question 7

presentation hereditary spherocytosis

Answer 7

anaemia
jaundice
splenomegaly
pigment gallstones

Question 8

DVT risk factors

Answer 8

• high BMI
• family history
• hypertension
• COCP
• female
• long period of stasis
• pregnancy

Question 9

what do white clots result in

Answer 9

• ischaemia

- infarction

Question 10

presentation pernicious anaemia

Answer 10

• fatigue
• malaise
• weakness
• easy bruising

Question 11

what is pernicious anaemia

Answer 11

It’s caused by an inability to absorb the vitamin B-12 needed for your body to make enough healthy red blood cells

Question 12

management B12 deficiency

Answer 12

IM injections every 3 months

Question 13

presentation B12/ folate deficiency

Answer 13

anaemia

neuro symptoms

Question 14

how do type 4 delayed hypersensitivity reactions work

Answer 14

initiated when tissue macrophages recognise danger and initiate inflammatory response

Question 15

examples type 4 hypersensitivity reactions

Answer 15

• coeliac
• contact dermatitis
• RA
• MS
• type 1 DM

Question 16

examples type III hypersensitivity reaction

Answer 16

• farmers lung
• SLE
• glomerulonephritis

Question 17

what areas have highest prevalence haemoglobinopathies

Answer 17

areas where malaria is endemic

e.g. west africa

Question 18

severe combined immunodeficiency (SCID)

Answer 18

present from birth, lymphocytes are not non-existent or not working properly

Question 19

polymorphism

Answer 19

A variation in the DNA that is too common to be due merely to new mutation. A polymorphism must have a frequency of at least 1% in the population. Examples of polymorphisms include the genes for sickle cell disease, thalassemia and G6PD deficiency.

Question 20

define significant risk neutropenia

Answer 20

<0.5 x 10^9

Question 21

normal neutrophil range

Answer 21

1.5-8 x 10^9

Question 22

what kind of infection causes raised monocytes

Answer 22

fungal