Haematological Malignancies

Question 1

What are the 2 main types of haematological malignancy?

Answer 1

Myeloid
Lymphoblastic

Split dependent on which blood cell precursor comes from

Question 2

How can myeloid maligncies be further split?

Answer 2

Acute

Chronic

Question 3

What is the acute myeloid malignancy?

Answer 3

Acute myeloid leukaemia

Question 4

What are the chronic myeloid malignancies?

Answer 4

Chronic myeloid leukaemia
Myelofibrosis
Polycythaemia vera
Essential thrombocytosis

Question 5

What are the lymphoid malignancies?

Answer 5

Acute lymphoblastic leukaemia
Chronic lymphoblastic leukaemia
Myeloma
Lymphoma

Question 6

What are the general effects of haematological malignancies?

Answer 6

Bone marrow failure
Constitutional symptoms
Infiltration

Question 7

What are the symptoms of bone marrow failure?

Answer 7

Anaemia
Thrombocytopenia
Recurrent infections

Question 8

What are the constitutional symptoms?

Answer 8

Weight loss
Fatigue
Infiltration

Question 9

What are the symptoms of infiltration?

Answer 9

Hepatomegaly
Splenomegaly
Lymphadenopathy

Question 10

How are haematological malignancies investigated?

Answer 10

Bloods

• FBC
• U&Es
• Calcium
• LDH

Tissue biopsy

CT/MRI

Bone marrow biopsy

• aspirate
• trephine

Flow cytometry

Immunohistochemistry