2. eicosanoids

Question 1

inhibit phospholipase A2

Answer 1

steroids

Question 2

irreversible inhibition of Cyclooxygenase

Answer 2

aspiri

Question 3

reversible inhibition of COX 1 and COX 2

Answer 3

NSAIDS
Diclofenac
Ibuprofen
Indomethacin
Mefenamic acid
naproxen
piroxicam

Question 4

selective inhibition of COX -2

Answer 4

selective COX 2 inhibitors
Celecoxib
etoricoxib

Question 5

leukotriene receptor blockers

competitive receptor antagonist

Answer 5

Zafirlukast

Montelukast

Question 6

potent anti-inflammatory drugs that inhibit production of arachidonic acid

Answer 6

steroids

Question 7

used to clos patent ductus arteriosus

Answer 7

indomethacin

ibuprofen -

for closure of a PDA in preterm and/or low birth weight infants, ibuprofen is as effective as indomethacin. It also causes fewer side effects (such as transient acute kidney injury) and reduces the risk of necrotising enterocolitis.

Question 8

Keeping a ductus arteriosus patent is indicated in neonates born with

Answer 8

concurrent heart malformations, such as transposition of the great arteries.

Question 9

can be used to keep a PDA open until the primary defect is corrected surgically

Answer 9

alprostadil, a PGE-1 analog