(P2) Inf. Dis: Schistosomiasis (the urinary bladder) (224) Flashcards
- name this slide*
- Name the structures:*
1. Dark large cells
2. The darker purple filler area w/ small purple cells
3. Entire large light circular structure in the center
Schistosomiasis (the urinary bladder)
- calcified egg
- fibrous connective tissue (fibrosis)
- Noncaseating Granuloma (chronic grnulomatosis inflammation surrounded by fibrosis)
Name the slide
- Name the top-left /lighter structure present in the Granuloma
- What is surrounding Granuloma
- Name the bottom/left DARKER structure in the Granuloma
Schistosomiasis (the urinary bladder)
- foreign body giant cell (nuclei not on edge)
- Fibrosis
- Non-calcified “egg” (schistosoma)
Schistosomiasis (the urinary bladder)
What are the 3 organisms that cause this disease and what organ do they infect?
S. mansoni and S. japonicum (liver / Gut)
&
S. haematobium (urinary bladder)
Schistosomiasis (the urinary bladder)
Route of transmission-Pathogenesis?
Water (cercarie released by snails) -enter human skin-reach blood vessels- travel to lugs, heart- undergo wide dissemination- reach hepatic vessels (veins) - maturation and migration of paired adult to:
According to morphologic classification of inflammation, the inflammatory reaction accompanying this lesion belongs to the following category ?
- category:*
- -granulomatous inflammation*
Schistosomiasis (the urinary bladder)
is the most important human helminthic disease known for causing complications:
1. Inflammation and fibrosis of the Urethral walls causing OBSTRUCTION
- Hydronephrosis and Chronic pyelonephrosis
- Squamous cell carcinoma of the bladder
Definitions:
Hydronephrosis is a condition that typically occurs when a kidney swells due to urine failing to properly drain from the kidney to the bladder. This swelling most commonly affects only one kidney,
- Causative agents*
- of* Schistosomiasis
- name 3:*
S. mansoni
S. japonicum
S. haematobium
Causative agent of Shicotsomiasis
(S . mansoni)
- Name geographic location*
- and*
- adverse effects it causes*
prevalent in S. America, Sub-Saharan Africa.
It inhabits lower mesenteric veins, affecting liver and distal l. intestine
Causative agent of Shicotsomiasis
(S. japonicum)
- Name geographic location*
- and*
- adverse effects it causes*
prevalent in SE Asia, S. China, Indochina.
It inhabits:
superior mesenteric veins affective liver, s. intestine, ascending l. intestine.
Causative agent of Shicotsomiasis
(S. haematobium)
Name geographic location
and
adverse effects it causes
prevalent in Sub-Saharan Africa and N. Africa countries such as Egypt, Tunisia, and Algeria.
It i_nhabits:_
veins of urinary bladder, rectum, pelvic organs.
Life Cycle: transmission
Schistosoma
Worms are transmitted by
freshwater snails
4 species:
- S. mansoni – bowel – spine on side
- S. haematobiam – urinary – apical spine
- S haponicum – round w/spine that goes around 4. S. japonicum - bowel
Schistosoma
Blooder involvement causing:
- Hematuria*
- Granulomatous disease of bladder*
- Chronic obstuctive uropathy*
- Renal failure*
- increases risk of cancer*
Defitition:
Obstructive uropathy is a structural or functional hindrance of normal urine flow, sometimes leading to renal dysfunction (obstructive nephropathy).
Schistosomiasis (the urinary bladder)
Q: According to morphologic classification of inflammation, the inflammaroty reaction accompanying this leasion belongs to the following category?
Granulomatous inflammation
Schistosomiasis (the urinary bladder)
Q: The animal associated in transmission of this disease?
Snail
Schistosomiasis (the urinary bladder)
In liver:
Name adverse effects
- Blocks bile ducts
- leads to cholestasis
- destruction of liver
- liver failure
- hydroperitoneum
