lecture 4

Question 1

adaptive immune response involves…

Answer 1

antigen recognition by specific receptors, lymphocyte activation, proliferation, differentiation, decline and memory

Question 2

What is a B cell receptor?

Answer 2

membrane-bound antibody (immunoglobulin)

Question 3

structure of BCR

Answer 3

2 heavy chains, 2 light chains, variable and constant regions

Question 4

structure of a T cell receptor (TCR)

Answer 4

heterodimer of alpha chain and ß chain; has variable and constant regions

Question 5

T and B cell repertoire

Answer 5

high diversity of BCR and TCR V regions

Question 6

Maturation of B lymphocytes location

Answer 6

in bone marrow

Question 7

maturation of T lymphocytes

Answer 7

in thymus

Question 8

maturation steps

Answer 8

commitment to the B cell/ T cell lineage → proliferation → somatic recombination → selection → differentiation into naive B and T cells

Question 9

V (D) J recombination

Answer 9

random combinations of germline gene segments and junctional diversity

Question 10

selection

Answer 10

elimination of self-reactive cells recognizing antigens in primary lymphoid organs

Question 11

mature naive B cells

Answer 11

co expression of membrane-bound IgM and IgD

Question 12

mature naive T cells

Answer 12

expression of either CD$ or CD8 molecule

Question 13

Where emigrate naive B cells, CD4+ or CD8+ T cells to?

Answer 13

• peripheral lymphoid organs

- may encounter foreign antigens