Lecture 6

Question 1

BCR recognize which kind of native molecules?

Answer 1

peptides, proteins, small chemicals etc.

Question 2

location of naive B cells

Answer 2

in follicles of peripheral lymphoid organs

Question 3

how are B cells activated?

Answer 3

antigen recognition, clonal expansion and differentiation into plasma cells, generation of memory B cells

Question 4

What is secreted by plasma cells?

Answer 4

antibodies

Question 5

What induces T cell dependent B cell response?

Answer 5

protein antigens

Question 6

How does the T cell dependent B cell response work?

Answer 6

B cell presents antigens to Th cell and receives activating signals from the T cell

Question 7

what is activated during primary and secondary immune response?

Answer 7

memory b cells

Question 8

what are germinal centers?

Answer 8

place of B cell affinity maturation and isotope switching

Question 9

explain affinity maturation

Answer 9

somatic mutations of immunoglobulin genes and selection of high-affinity B cells by follicular dendritic cells (FDC)

Question 10

What induces immunoglobulin isotope switching?

Answer 10

induced by antigen-activated B cells that receive signals from helper T cells (CD40L, cytokines)

Question 11

What define antibody isotopes (classes)

Answer 11

their effector function

Question 12

list effector functions of antibodies

Answer 12

1. neutralization
2. phagocyte activation
3. antibody-dependent cellular cytotoxicity
4. antibody-mediated helminth killing
5. complement activation by classical pathway, mucosal immunity (IgA)

Question 13

how are antibodies recognized?

Answer 13

by Fc receptors on different cells