Physiology of Normal White Blood Cells Flashcards

1
Q

Cytokines

A

low molecular weight, regulatory proteins/glycoproteins
messenger molecules, secreted by wbcs
assist in regulating the development of immune effector cells
act locally - paracrine signalling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chemokines

A

induce directed chemotaxis in local responsive cells
act as attractants for leucocytes, recruit monocytes and neutrophils
e.g. MCP-1 - monocyte chemotactic protein 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inflammation

A

bacteria trigger macrophages to release cytokines and chemokines
vasodilation, migration
components: BVs, phagocytes, plasma proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cell adhesion to endothelium

A

Initial Contact: P selectin and E selectin on endothelium recognised by oligosaccharides on leucocytes
Tighter adhesion: intercellular adhesion molecules (ICAMs) on endothelium recognised by integrins on leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Recognition

A

macrophage mannose receptor: ligand is conserved carbohydrate structure
scavenger receptor: ligand is anionic polymers, acetylated and oxidised LDL
toll like receptor: various ligands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Atherosclerosis - 3 areas of pathogenesis

A

endothelial cell dysfunction
inflammation
dysregulation of lipid metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Damage of endothelium

A

production of chemokines and cytokines
recruitment of monocytes
development into foam macrophages/foam cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Damage to endothelium & Deposition of lipids

A

potential exposure of collagen

platelet activation and coagulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly