Dyslipidaemia

Question 1

Ezetimibe

Answer 1

selective inhibitor of absorption of cholesterol in small bowel
Inhibition of membrane transporter
10mg/day = 20% reduction in LDL C and 8% reduction in TG

Question 2

PCSK9 inhibitors

Answer 2

Monoclonal antibodies

prevent LDLR degradation

Question 3

Hypercholesterolaemia

Answer 3

Increased TC and LDLC

Question 4

Mixed hyperlipidaemia

Answer 4

Increased TC, LDLC, TG

Decreased HDLC

Question 5

Hypertriglyceraemia

Answer 5

Causes harm through acute pancreatitis
Less common
Familial

Question 6

Lipoprotein a

Answer 6

Made by liver
LDL like + Apo A + Apo B associated with MI/stroke/aortic stenosis
ApoA. -glycoprotein; atherosclerosis and thrombosis

Question 7

Treatment - lipid apheresis

Answer 7

80-90% decrease in CV events

Question 8

Anti PCSK9 - efficacy

Answer 8

Decrease cholesterol by 25%

Question 9

Antisense therapy

Answer 9

Decreased levels of LP(a) by 90% - small molecules bind to apo (a) mRNA in nucleus

Question 10

Familial hypercholesteraemia

Answer 10

autosomal dominant (mutations in LDLR gene)