Aspirin

Question 1

Aspirin indications

Answer 1

ACS, Stroke, CVD, cerebrovascular, peripheral arterial disease, AF (when DOAC/warfarin C/I) to reduce thrombus, mild-to-moderate pain/fever

Question 2

Aspirin MOA

Answer 2

Irreversibly inhibits COX, reducing production of thromboxane and arachidonic acid, reducing platelet aggregation

Question 3

Aspirin side effects

Answer 3

GI irritation, GI ulcer, haemorrhage, tinnitus in high dose, aspirin overdose is dangerous

Question 4

Aspirin C/I

Answer 4

Children under age of 16 due to Reye’s syndrome, third trimester of pregnancy , gout (can trigger acute attack), peptic ulceration

Question 5

Aspirin interactions

Answer 5

Co-dynamic with other antiplatelets/anticoagulants

Question 6

Maximum daily dose of aspirin for pain

Answer 6

4g in divided doses

Question 7

GI complication risk factors

Answer 7

> 65, previous peptic ulcer disease, comorbidities e.g. CVD , Diabetes , other drugs with GI effects like prednisolone and NSAIDS