Aminosalicylates

Question 1

Aminosalicylates examples

Answer 1

mesalazine and sulfasalazine

Question 2

Aminosalicylates indications

Answer 2

mesalazine used for ulcerative colitis first line, sulfasalazine used for rheumatoid arthritis

Question 3

aminosalicylate MOA

Answer 3

Release 5-Aminosalicylic acid 5ASA it has anti-inflammatory and immunosuppresive effects

Question 4

aminosalicylate side effects

Answer 4

GI upset, headache, leucopenia, thrombocytopenia, renal impairment , reduce sperm, serious hypersensitivity reactions

Question 5

When to avoid aminosalicylates

Answer 5

avoid in those with issues with aspirin like aspirin hypersensitivity

Question 6

Aminosalicylate interactions

Answer 6

mesalazine tablets e.g. asacol mr has pH sensitive coating that may interact with drugs altering pH like PPI resulting in coating breaking own early, lactulose also lowers stool pH