Primary Hyperaldosteronism Flashcards
What is primary hyperaldosteronism?
Excess production of aldosterone, independent of the renin-angiotensin system
What are two common causes of PH?
Conn’s Syndrome, bilateral adrenocortical hyperplasia
What is Conn’s Syndrome?
Solitary aldosterone-producing adenoma
What does hyperaldosteronism lead to?
An increase in sodium and water retention, a decrease in renin release
When should you consider PH?
If patient has HTN, hypokalaemia, alkalosis
What are the key presentations of PH?
HTN, nocturia and polyuria, mood disturbance, difficulty concentrating
What investigations would you do?
Plasma potassium - low, aldosterone:renin - high
How do you manage Conn’s?
Laparoscopic adrenalectomy
What are potential complications of PH?
HTN, hypokalaemia
How do you manage bilateral adrenal hyperplasia?
Spironolactone, an aldosterone antagonist
What are renin/aldosterone levels in primary hyperaldosteronism?
Renin decreased, aldosterone increased
What are renin/aldosterone levels in secondary hyperaldosteronism?
Both raised
