Derm Flashcards

1
Q

What is acanthosis nigricans associated with?

A
Gastric carcinoma 
Obesity
DM
Acromegaly 
Hodgkins lymphoma 
Thyroid disease
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2
Q

List 2 drug causes of alopecia

A

Warfarin and heparin

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3
Q

List causes of hirsuitism

A
PCOS 
Adrenal / ovarian tumours 
Cushings 
Acromegaly 
CAH 
Steroids
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4
Q

What is 1st line Tx for eczema?

A

Emollients and topical steriods

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5
Q

List causes of onycholysis

A
Psoriasis 
Dermatitis 
Infection (fungal) 
RA 
Hypothyroidism 
Trauma 
Idiopathic
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6
Q

Where are psoriatic lesions found?

A

Extensors

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7
Q

What is 1st line Tx for psoriasis?

A

Topicals eg tar, dithranol, Vit D, steriods

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8
Q

List cells in the epidermis

A

Keratinocytes
Melanocytes
Langerhans cells
Merkel cells

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9
Q

What are skin appendages?

A

Structures derived from ecto/mesoderm and housed within skin

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10
Q

Give examples of skin appendages?

A

hair follicles, sebaceous glands, apocrine sweat glands, eccrine sweat glands, nails

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11
Q

White/red patches of buccal mucosa. Dx?

A

Oral candidiasis

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12
Q

Tx for oral candidiasis?

A

Nystatin

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13
Q

Chronic itchy blistering skin is associated with what GIT condition? What is it called?

A

Coeliacs

Dermatitis Herpetiformis

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14
Q

What is the Mx for dermatitis herpetiformis?

A

Dapsone (sulphone ABx)

Avoiding gluten based foods

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15
Q

What are the dermatological manifestations of neurofibromatosis type 1?

A

Cafe au lait spots
Neurofibromas
Axillary freckling

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16
Q

What are the dermatological manifestations of neurofibromatosis type 2?

A

Cafe au lait spots (less than type 1)

Bilateral vestibular schwannomas

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17
Q

What type of inheritance is neurofibromatosis?

A

Autosomal dominant

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18
Q

List 3 causes of generalised cutaneous hypo pigmentation

A

Pheylketonuria
Albinism
Hypopituitarism

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19
Q

List 5 causes of localised cutaneous hypo pigmentation

A
Vitiligo 
Pityriasis veriscolor 
Post inflammation skin conditions
Tuberous sclerosis 
Leprosy
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20
Q

Indolent boils which rapidly expand, break down and leave large, ulcerated painful areas with a characteristic undermined edge. Dx?

A

Pyoderma gangrenosum

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21
Q

List 3 conditions associated w pyoderma gangrenosum

A

UC, CD, RA

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22
Q

What is Mx for pyoderma gangrenosum

A

Systemic steroids in moderately high doses

Dressings

23
Q

List 5 conditions in which orogenital ulceration is seen

A
IBD 
Steven-Johnson syndrome 
Syphillis 
Behcet's disease 
Reiters syndrome
24
Q

Chronic sarcoid plaques resembling blue-red plaques on nose and hands. Dx?

A

Lupus pernio

25
Q

What condition is lupus pernio associated with?

A

Sarcoidosis

26
Q

What is Bowen’s disease?

A

Intra-epidermal carcinoma in situ

Can progress to invasive SCC

27
Q

What is triad of Sx for tuberous sclerosis?

A

Cutaneous abnormalities
Mental retardation
Seizures

28
Q

What nutritional deficiency results in pellagra?

A

Nicotinic acid

29
Q

What is the Sx triad of pellagra?

A

Dermatitis, diarrhoea, dementia

30
Q

Skin that is hot, red, tender with poorly demarcated edges. Dx?

A

Cellulitis

31
Q

Name common organisms that cause cellulitis

A

Staph aureus

Strep pyogenes

32
Q

Tx of cellulitis?

A

IV flucloxacillin

33
Q

Brown firm nodules on neck. Diascopy show ‘apple jelly’ appearance. Dx?

A

Lupus vulgaris (cutaneous TB)

34
Q

Tx for Lupus Vulgaris?

A

TB medication for 1 year

35
Q

What drugs are used to treat TB?

A

Oral rifampicin, pyrazinamide, isoniazid, ethambutol

36
Q

Ulcerated, expanding nodule with everted edges. Occurring on face/neck. Dx?

A

SCC

37
Q

Other than in sun damaged areas, where can SCC occur?

A

Edges of scars

38
Q

What is the scoring system for melanoma?

A

Glasgow 7 point system

39
Q

List elements of Glasgow 7 point system

A

MAIN: Size, shape, colour
MINOR: Diameter >7mm, inflammation, oozing/bleeding, itching

40
Q

What is the main type of melanoma?

A

Superficial spreading

41
Q

What is the system for measuring invasion of melanoma into skin?

A

Breslow thickness

42
Q

Erythematous plaques on chest and back which look like psoriasis. FLAWS & other cancer Sx. Dx?

A

Cutaneous lymphoma

43
Q

Peri-oral pigmentation. Dx?

A

Peutz-Jegher’s syndrome

44
Q

What organism causes molluscum contagiosum?

A

Pox virus

45
Q

Pearly elevated, smooth, reddish papule with a central punctum. Dx?

A

Molloscum contagiosum

46
Q

Tx for moderate acne on face, neck and back?

A

Oral erythromycin

47
Q

What drug causes drug induced SLE Sx?

A

Sulphonamides like trimethoprim

48
Q

Define nodule

A

Solid lump >0.5cm which is subcut/intradermal

49
Q

Define macule

A

Well defined flat area of altered pigmentation

50
Q

Define Papule

A

Raised, well defined lesion usually <0.5cm

51
Q

Define pustule

A

Well defined pus filled lesion

52
Q

List causes of erythema multiform

A
Idiopathic 
Infections - HSV, strep, EBV 
SLE 
Cancer 
Sarcoidosis 
Cancer 
Drugs - penicillin, sulphamides
53
Q

List causes of erythema nodosum

A
Sarcoidosis 
IBD 
Blood cancers 
Strep, TB, EBV 
Drugs like OCP or penicillin
54
Q

Which of these is NOT a skin change of diabetes?

Neuropathic ulcer, necrobiosis lipodica, acanthosis nigracans, lipohypertrophy, livedo reticularis?

A

Livedo reticularis