Session 7- Adaptive immune response (Effector phase) Flashcards
what recognises the receptor in t lymphocytes
TCR - t cell receptor made up of alpha and beta chains
what is an antigen recognition receptor made up of
t cell receptor
CD3 complex
Accessory molecules (CD4- MHC class II or CD8- MHC Class II)
what do effector CD4+ T cells become
T helper cells
what do effector CD8+ T cells become
Cytotoxic T cells
what does the b cell antigen receptor consist of
b cell receptor or BCR: membrane bound antibodies
unique specificity for each cell
what do b lymphocyte antigen receptors recognise
macromolecules and small chemicals
what is the outcome of lymphocyte activation
anitbody production
- IgM production is T helper independant
- IgA, IgG IgE production is T helper dependant- isotope switch
affinity maturation in antibody response
-prolonged or repeated exposure
memory B cells
-upon re-challenge can give a faster, stronger and longer antibody response
which antibody is produced first
IgM- shows recent infection
effector function of IgG
Fc-dependent phagocytosis
complement activation
neonatal immunity
toxin/virus neutralization
funtion of IgE
immunity against helminths
mast cell degranulation
IgA funtion
mucosal immunity
appears when infection is long term
IgM function
complement activation
