Session 9- Immunocomprimsed host Flashcards
Main cause of primary immunodeficiency diseases
Congenital
Due to intrinsic gene defect
Defects in B cell development
X-Linked agammaglobulinaemia
Defect in antibody production
Common variable immunodeficiency - most prevalent that require treatment
Selective IgA deficiency - most prevalent that doesnt require treatment
Combined T cell and B cell defect
Severe combined immunodeficiency SCID
T cell defects
Di George syndrome
Phagocytic defect
Chronic granulomatou disease- normally presents with skin infections/ abscess, pulmonary aspergillosis
Onset < age 6 months
T cell or phagocyte defect
Onset > 6 months and <5 years old
B cell, antibody or phagocyte defect
Onset >5 years old and later in life
B cel/ Antibody/ complement/ pr secondary immunodeficiency
Supportive treatment
Infection prevention
Treat infections promptly and aggressively
Nutritional support
Use IV-irradiated
Avoid live attenuated vaccine
Specific treatment
Immunoglobulin replacement therapy- goal for serum IgG >8g/L and used CVID , Brutons disease, IgA deficiency, hyper IgM syndrome
Haematopoeitic stem cell therapy
Comorbidities
Autoimmunity and malignancies
Organ damages (lung function assessment)
Avoid non-essential exposure to radiation
Why are secondary immunodeficiency diseases developed
Decreased production immune components due to malnutrition, infection, liver diseases, haematogical malignancies, therapeutic treatment
Increased loss of immune component due to protein- losing conditions or burns
Increased susceptibility to infections to chemo
What is an immunocomprimsed host
• “State in which the immune system is unable
to respond appropriately and effectively to infectious microorganisms”
When t suspect an immunodeficiency
SPUR infections
Severe
Persistent
Unusual
Recurrent
