Lecture 5 Approach to the Yellow Baby

Question 1

Name something that are elevated in hepatocellular damage

Answer 1

ALT/AST

Question 2

Name 2 things that are elevated in biliary disease

Answer 2

Alkaline phosphatase

Gamma Glutamyl Transferase (GGT)

Question 3

Name 5 tests carried out to assess liver function

Answer 3

Prothrombin time
APTT
Albumin
Bilirubin
Blood glucose
Ammonia

Question 4

Name causes of unconjugated infant jaundice

Answer 4

Breast milk
Seosis
Haemolysis (ABO incompatibility, RhD, G6DP deficiency, spherocytosis) Gilberts disease, Crigler-Najjar syndrome

Question 5

Name causes of conjugated infant jaundice

Answer 5

Neonatal hepatitis
Biliary obstruction
Biliary atresia
Choledochal stools
Alagille syndrome

Question 6

Pale stools and dark urine would suggest what type of jaundice

Answer 6

Biliary atresia
Biliary obstruction
Conjugated

Question 7

What are the complication of biliary atresia

Answer 7

Liver failure

Question 8

What is the treatment of biliary atresia

Answer 8

Kasai Portoenterostomy

Question 9

What does the split bilirubin indicate

Answer 9

Checks that the baby’s blood ratio of conjugated and unconjugated

Question 10

Name causes of Neonatal Hepatitis

Answer 10

Viral hepatitis
Hypoparathyroidism
Urea cycle defects
Glycogen storage disorders
Alpha-1-antitrypsin deficiency