Multiple endocrine neoplasia

Question 1

define multiple endocrine neoplasia?

Answer 1

an autosomal dominant condition characterised by a predilection to develop tumours of endocrine glands.

Question 2

what is the inheritance pattern of MEN?

Answer 2

• Autosomal dominant inheritance

Question 3

which cancers are common with MEN type1?

Answer 3

- adrenal and thyroid 
3 Ps 
- parathyroid 
- pituitary 
- pancreas

Question 4

which cancers are common with MEN type 2a?

Answer 4

2Ps
Parathyroid (60%)
Phaeochromocytoma

Question 5

which cancers are common with MEN type 2b?

Answer 5

1P
Phaeochromocytoma
Marfanoid body habitus
Neuromas

Question 6

what is a typical presentation of MEN type 1 ?

Answer 6

o Peptic ulceration
o Galactorrhoea
o Hypercalcaemia

Question 7

which gene is associated with MEN type 1?

Answer 7

MEN1 gene

Question 8

which gene is associated with MEN type II?

Answer 8

RET oncogene

Question 9

how to investigate for Phaeochromocytoma ?

Answer 9

24 hr urine metanephrines

Question 10

how to investigate for Medullary thyroid cancer ?

Answer 10

elevated calcitonin concentration

Question 11

how to investigate for parathyroid tumours?

Answer 11

simultaneously elevated Ca2+ and PTH