A:2. clinical use and Side effects of drug

Question 1

Famotidine

Answer 1

Cl: GERD, peptic, gastric ulcer
SE: Nausea, headache, skin rash, diarrea

Question 2

Pantoprazol

Answer 2

Cl: GERD, Zolinger, Ulcer
SE: 
- osteoporosis,
- hypergastrinemia
- bacterial overgrowth
- Leukopenia
- skin rash

Question 3

Contraindication of antiacids

Answer 3

weak base ( increases the absorption) 
weak acid ( warf, doxycycline) decrease absorprion

Question 4

SE of lopramide, diphenoxylate

Answer 4

• RR decreased
• HR, Temp increase
• Dry mucous + skin

Question 5

SE of palonosetron, ondansetron

Answer 5

• Increased QT time
• constipation
• dizziness

Question 6

SE metoclopramide

Answer 6

• EPS

- Hyperprolactinemia

Question 7

SE of ergotamin

Answer 7

• Increased BP
• GI ischemia
• central + peripheral vasospasm

Question 8

SE Levodopa

Answer 8

• Hypotension, arrythima, nausea, Anorexia

- Hallucination, depression, dyskineasis

Question 9

SE pramipexol, ropinirole

Answer 9

• Nausea, vomit, arrythima, Hypotension

Question 10

SE ethusoximide

Answer 10

• Fatigue
• dizziness
• Gi distress
• SJS
• Headache

Question 11

SE valproic acid

Answer 11

• Hepatotoxic
• Pancreatitis
• Alopecia
• Weight gain
• Teratogenic

Question 12

SE lamatrogine

Answer 12

• SJS

- Hematologic disease

Question 13

SE and Pk of Phenytoin

Answer 13

Pk: zero order kinetic of elimination, CYP450 +
SE: CNS depression, gingival hyperplasia, hirtuism, teratogenic.

Question 14

Ix and SE of carbmazepine

Answer 14

Ix: Trigeminal neuralgia, central diabetes insipidus
SE: Teratogenic, SJS, increased ADH

Question 15

SE of vigabatrin

Answer 15

• Visual loss
• psycosis
• sedation

Question 16

SE phonobarbital

Answer 16

Sedation
resp depressin
hypotension
SJS

Question 17

SE of Lithium

Answer 17

• Hypothyroidism
• Nephrogenic diabetes insipidus
• Decreased cardiac function
• Edema
• Teratogenic

Question 18

SE SSRI

Answer 18

• Central: Psycosis, insomina, tremor, anxiety

- GI: Weightloss, diarreha nausea

Question 19

SE reboxetine

Answer 19

Cardiotoxic

Question 20

SE bupropion

Answer 20

• dry mouth, sweat, seizure, tremor

Question 21

SE maoi

Answer 21

• Orthostatic hypotension
• Cheese effect
• Insomina
• Irritability
• Sexual disturbance

Question 22

SE clozapine

Answer 22

Agranulocytosis
orthostatic hypotension
weight gain
sedation

Question 23

Se 2nd gen antipsycotic

Answer 23

• Not as high EPs rest is: ort hypotension, sedation, weight gain

Question 24

SE 1st gen antipsycotic

Answer 24

• EPS ( Dyskineasis)
• Dysphoria
• Endocrine dysfunction ( increased temp, weight)
• Muscarinic and alpha effect

Question 25

Se: Benzodiazepine

Answer 25

- Sedation - Tolerance - Anterograde amnesia - Resp depression (if underlying disease)

Question 26

SE ketamine

Answer 26

Increased BP, ICP, Hallucination, no m. relax

Question 27

SE Thiopental

Answer 27

decreased: BP, Resp, ICP, INcreased: HR