A&P Chapter 19 Heart Flashcards Preview

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Flashcards in A&P Chapter 19 Heart Deck (41):

The only thing that moves blood is?

A Change in Pressure, blood moves from a high pressure to a low pressure. The heart plays a role in changing pressures.


What are the two Circuits of the cardiopulmonary system?

The Pulmonary Circuit where CO2 filled blood leaves the heart and enters the lungs returning to the heart with O2.

The Systemic Circuit where O2 filled blood leaving the heart travels to every part of the body to deposit O2 and pick up CO2.


Describe the Heart

It is a pump, approx. 250-300grams.

It is located in the MEDIASTINUM.

It is anterior to vertebrae and posterior to the sternum. The base of the heart begins at about the 2nd rib and the apex ends at about the 6th rib.

The heart is superior to the diaphragm and is surrounded by the lungs.

ALL VESSELS, NERVES, Ect...enter and leave the heart at the BASE.


From Inner to Outer what are the layers of the heart?

Endocardium: a thin simple squamous epithelia.
Myocardium: the THICK layer of cardiac muscle.
Epicardium: the thin layer of dense irregular connective tissue.


Which layer of the heart is the only one to contract?

The Myocardium


Describe a Myocardiocyte

The are striated muscle cells with usually one nucleus but they can have two. They are much shorter than skeletal muscle cells and they are attached to one another by INTERCALATED DISCS which are made of SUPER STRONG DESMOSOME connections which hold the cells together tightly and GAP JUNCTIONS which allow ions and cell signaling molecules to travel between cells very quickly.


What is the layer that surrounds the heart?

The Pericardium


Describe the Serous Pericardium:

It is a double layer of connective tissue that helps to hold the heart in place and allows the heart to rotate at the apex with very little to no friction.

There is a VISCERAL layer which is the EPICARDIUM and surrounds the heart directly.

There is a PARIETAL layer which remains still when the heart beats and is attached to the structures around the heart.

The space between the layers is the PERICARDIAL CAVITY filled with a serous fluid comprised of phospholipids.


Describe the Fibrous Pericardium

It is a much thicker layer of dense irregular connective tissue that surrounds the Serous Pericardium. It is very strong and if blood or something fills the pericardial cavity it can limit the ability of the heart to beat, expand and contract. This is the case with a Cardiac Tamponade


What layer of the heart do the Coronary Arteries and the Cardiac Veins run in?

The Epicardium/Visceral Layer of the Serous Pericardium.


What is an Anastomosis? What function do they serve? Why are they potentially important?

They are locations where two arteries or veins combine and flow into each other. This allows blood to flow back around to the other side of a blockage thus perfusing tissue, potentially preventing an MI.


Where do the branches of the coronary arteries and cardiac veins travel?

They travel deep to the Epicardium into the Myocardium to supply capillary beds in the cardiac muscle tissue.


How much Serous fluid is in the Pericardial Cavity at a given time?



Where does the Coronary Sinus empty?

The Right Atrium


What chamber of the heart pumps the largest volume of blood?

None: they all pump the same volume of blood.


What is a Ventricular Septal Defect?

A hole most likely located in the thinnest part of the interventricular septum between the right and left ventricles.


Where are there no valves controlling the flow of blood?

From the superior and inferior vena cavae in the Right Atrium.

From the pulmonary veins flowing into the Left atrium.


What prevents the atrioventricular valves from inverting into the atria?

The cordae tendonae connected to the papillary muscles.


Which valve in most older men leaks? What does leaky valves lead to?

The Left Atrioventricular Valve, it can lead to heart failure.


Describe the cardiac conduction system starting with the SA Node through the Purkunjie fibers

The Sinoatrial Node depolarizes resulting in the depolarization of the Atria. The specialized cells in the SA node spontaneously depolarize and with the gap junctions between the cardiomyocytes will propagate the action potential to all the other cells in the atria.

The Atrioventricular Node has a slight delay before firing, once it does it sends the signal down the Atrioventricular Bundle (of His), from the Bundle of His it splits into the Bundle Branches before travelling down to the Purkunjie fibers. The depolarization of the Ventricles begins at the apex from the action potential generated by the Perkunjie fibers.


Where is the only place where there are gap junctions in the cardiomyocytes between the atria and ventricles?

The atrioventricular bundle.


Why does the action potential traveling down the Bundle branches NOT depolarize cardiomyocytes until it travels all the way to the Purkunjie fibers?

Because there are NO gap junctions between the cardiomyocytes that make the Bundle of His or the bundle branches, it is only down at the apex of the heart in the Purkunjie fibers do the cardiomyocytes of the Purkunjie fibers form gap junctions with the rest of the surrounding cardiomyocytes which allows the action potential to spread UP the heart towards the base pushing blood UP and into the Aorta and the Pulmonary Trunk.


Where are there NO Gap junctions between cardiomyocytes in the heart?

Between the Atria and Ventricles EXCEPT at the Atrioventricular Bundle and along the Interventricular septum.


Where would a block in the cardiac conduction system be fatal?

In the Atrioventricular Bundle


If the Sinoatrial Node did not fire would you die? What would happen?

No this is known as a Nodal rhythm where the Atrioventricular node will fire on it's own. It isn't as efficient as when the Sinoatrial Node triggers the Atrioventricular node.

If this happens the ventricals will contract but the Atria will NOT. This isn't fatal because the negative pressure in the ventricles will pull the blood from the atria into the ventricles.


Give a brief description of how the flow of ions results in an action potential and a contraction in cardiac muscle.

Na+ ions flow into the cell until threshold is reached at which point the K+ channels open and begin allowing K+ out of the cell to begin repolarization. The action potential generated by the membrane voltage change travels across the sarcolemma down the T-Tubles to the Terminal Cisternae resulting in VOLTAGE gated Ca2+ channels on the Sarcoplasmic reticulum being opened flooding the inside of the cell with Ca2+. The Ca2+ binds with troponin which changes it's conformation resulting in the movement of the tropomyosin from the active sites on the actin myofilaments. This allows cross bridges to be formed and a contraction to occur.


Contraction of the heart (or anyone of its chambers) is known as?



Relaxation of the heart (or anyone of its chambers) is known as?



One systole followed by one diastole is one what?

Cardiac Cycle


If someone refers to a systole or diastole of the heart and they don't specify any specific area of the heart where are they referring to?

The Left Ventricle


Describe an EKG wave form, give the names of the waves and what is happening to the heart during each phase.

Step 1: Forms the P wave, the atria begin depolarizing.

Step 2: Atrial depolarization is complete, the P wave is complete this is followed by a short flat line.

Step 3: Ventricular depolarization begins at the apex and progresses superiorly WHILE the atria are repolarizing, this is the QRS complex.

Step 4. Ventricular Depolarization is complete, this completes the QRS complex and is followed by a flat line.

Step 5. Forms the T wave, the Ventricular Repolarization begins at the apex and progresses superiorly.

Step 6. The T wave is complete and the Ventricles have repolarized and the cardiac cycle is complete.


Why do you not see a P wave on a Nodal Rhythm?

The Sinoatrial node does not fire and thus the Atria do NOT contract so NO P wave is recorded on the ECG.

The AV node takes over and the ventricles depolarize, contract and relax.


What happens in Fibrillation? What does a Defibrillator do in this situation?

In Fibrillation the electrical signals are spreading in a random pattern all over the heart. No coordinated contraction occurs and the heart does not beat.

A Defibrillator shocks the heart with enough voltage to reset ALL of the cardiac myocytes at once allowing the proper distribution of electrical signals to begin again.


What is missing on the ECG in a heart block? Where is the problem at in the cardiac conduction system?

The QRS Complex and the T wave are absent from an ECG reading.

The problem occurs at the Atrioventricular Bundle (of His) in which damage to the bundle is not allowing the electrical signal to flow down to the Purkunjie fibers and depolarize the Ventricles.


The flow of blood through the heart is controlled by what?

Changes in pressure.

The open and closing of valves depends entirely on the difference in pressure from one side to the other. Higher pressure will push a valve open or closed.


What is Heart rate?

The Number of beats/min.


What is Stroke Volume?

The volume of blood ejected from a ventricle during a single systole. Assume the Left ventricle unless specially told otherwise. Average stroke volume is approx. 70ml's.


What is Cardiac Output? How do you calculate it?

Cardiac output is the volume of blood ejected by a ventricle in one minute.

CO=HR X Stroke Volume.


What is Cardiac Index?

The volume of blood pumped by a ventricle per minute per square meter of body surface.


How can you change your cardiac output?

By increasing/decreasing the heart rate or the stroke volume. In reality increases/decreases in both occur at the same time.


What is the Frank-Starling Law of Cardiac Contraction?

That your ventricles modify both heart rate and stroke volume on a beat by beat basis and that this depends on how much the cardiac muscle cells are stretched during the preceding diastole, which itself depends on the volume of blood in the chamber.