A14. Skeletal muscle relaxants acting on the neuromuscular junction

Question 1

List the Curare type drugs.

Answer 1

1. Doxacurium
2. Pancuronium
3. Pipecuronium
4. Vecuronium
5. Rocuronium
6. Atracuronium
7. Cisatracurium
8. Mivacuronium

Question 2

Succinulcholine (Suxamethonium)?

Answer 2

??

Question 3

List the skeletal muscle relaxants that work on the NMJ.

Answer 3

1. Postsynaptic: Pancuronium Pipecuronium Vecuronium, Rocuronium, Doxacurium, Atracurium (> laudanosin) Cisatracurium Mivacurium, tubocurarine Succynylcholine Dantrolene
2. Presynaptic: botulinum toxin ɷ-conotoxin aminoglycosides tetracyclines.
3. Antagonists: neostigmine distigmine Sugammadex

Question 4

List the skeletal muscle relaxants that act postsynaptically on the NMJ.

Answer 4

1. Pancuronium
2. Pipecuronium
3. Vecuronium
4. Rocuronium
5. Doxacurium
6. Atracurium (> laudanosin)
7. Cisatracurium
8. Mivacurium
9. Tubocurarine
10. Succynylcholine
11. Dantrolene.

Question 5

List the skeletal muscle relaxants that acts presynaptically on the neuromuscular junction.

Answer 5

1. Botulinum toxin
2. ɷ-conotoxin
3. Aminoglycosides
4. Tetracyclines

Question 6

List the skeletal muscle relaxants which are antagonist at the NMJ.

Answer 6

1. Neostigmine
2. Distigmine
3. Sugammadex

Question 7

List the short acting curare drugs.

Question 8

List the medium acting curare drugs.

Question 9

List the long acting curare drugs.

Question 10

What are the side effects of curare drugs?

Question 11

What are the reverse effects of curare?

Question 12

Potentiation

Question 13

What is the MOA of succinylcholine (suxamethonium)?

Question 14

What are the side effects of Succinylcholine?