Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

ABSITE > ABSITE - oncology > Flashcards

ABSITE - oncology Flashcards

(60 cards)

Start Studying
1
Q

mechanism of cisplatin

A 
cell-cycle non-specific
alkylate DNA (covalent bond)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mechanism of carboplatin

A 
cell-cycle non-specific
alkylate DNA (covalent bond)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

mechanism of oxaliplatin

A 
cell-cycle non-specific
alkylate DNA (covalent bond)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

mechanism of cyclophosphamide

A

cell-cycle non-specific
alkylate DNA (covalent bond)
acrolein is active metabolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

mechanism of busulfan

A 
cell-cycle non-specific
alkylate DNA (covalent bond)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

mechanism of bleomycin

A 
cell-cycle non-specific
alkylate DNA (covalent bond)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

mechanism of streptozocin

A

cell-cycle non-specific
alkylate DNA (covalent bond)
glucose mimic to islet cells -> kills islet cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

mechanism of methotrexate

A

S-phase specific

inhibits dihydrofolate reductase -> inhibits purine/DNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

mechanism of 5-fluorouracil

A

S-phase specific

inhibits thymidylate synthase -> inhibits purine/DNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

mechanism of etoposide

A

S-phase specific

inhibits topoisomerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

mechanism of doxorubicin (Adriamycin)

A

S-phase specific

DNA intercalator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

mechanism of alkaloids (vincristine, vinblastine)

A

M-phase specific

inhibits microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

mechanism of taxanes (docetaxel, paclitaxel)

A

M-phase specific

promote irreversible microtubule formation/stabilization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

mechanism of irinotecan

A

S-phase specific

inhibits topoisomerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

mechanism of gemcitabine

A

S-phase specific

nucleoside analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

mechanism of anastrozole

A

aromatase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

mechanism of leuprolide

A

GnRH analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

mechanism of flutamide

A

anti-androgen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

mechanism of trastuzumab (Herceptin)

A

monoclonal antibody

blocks HER/neu receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

mechanism of bevacizumab (Avastin)

A

monoclonal antibody
blocks VEGF receptor
inhibits angiogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

mechanism of imatinib (Gleevec)

A

receptor tyrosine kinase inhibitor

binds c-kit (stem cell growth factor receptor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

mechanism of cetuximab (Erbitux)

A

monoclonal antibody

blocks EGF receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

adverse effects of cisplatin

A 
nephrotoxicity
neurotoxicity
ototoxicity
hypocalcemia/hypomagnesemia
severe peripheral neuropathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

adverse effects of carboplatin

A 
(bone-)myelosuppression
nephrotoxicity
neurotoxicity
ototoxicity
hypocalcemia/hypomagnesemia
peripheral neuropathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
adverse effects of oxaliplatin
``` cold sensitivity nephrotoxicity neurotoxicity ototoxicity hypocalcemia/hypomagnesemia peripheral neuropathy ```
26
adverse effects of busulfan
pulmonary fibrosis
27
adverse effects of bleomycin
pulmonary fibrosis
28
adverse effects of doxorubicin
heart failure cardiomyopathy hepatotoxicity
29
adverse effects of cyclophosphamide
``` severe pancytopenia pulmonary fibrosis second malignancy hemorrhagic cystitis gonadal dysfunction SIADH ```
30
adverse effects of methotrexate
``` oral ulceration diarrhea Stevens-Johnson hepatitis encephalopathy nephrotoxicity ```
31
mechanism of capecitabine
S-phase specific | converts to 5-fluorouracil in tumor
32
adverse effects of 5-fluorouracil
``` oral ulceration diarrhea Stevens-Johnson hepatitis encephalopathy nephrotoxicity ```
33
adverse effects of vincristine
peripheral neuropathy neurotoxic paralytic ileus
34
adverse effects of vinblastine
(bone-)myelosuppression | paralytic ileus
35
adverse effects of taxanes (docetaxel, paclitaxel)
``` pancytopenia cardiotoxicity when used with adriamycin peripheral neuropathy allergic reactions peripheral edema ```
36
adverse effects of tamoxifen
DVT | endometrial CA
37
adverse effects of anastrozole
fractures
38
adverse effects of bevacizumab (Avastin)
bowel perforation | inhibit wound healing
39
adverse effects of imatinib (Gleevec)
CHF
40
clinical use of doxorubicin
breast CA | sarcoma
41
clinical use of cyclophosphamide
lymphoma sarcoma non-GI adenocarcinoma
42
clinical use of cisplatin
lung CA squamous cell Ca ovarian CA germ cell tumors
43
clinical use of carboplatin
lung CA squamous cell Ca ovarian CA germ cell tumors
44
clinical use of oxaliplatin
colon CA
45
clinical use of taxanes (docetaxel, paclitaxel)
breast CA ovarian CA lung CA
46
clinical use of tamoxifen
pre-menopausal prevention of breast CA | treatment of pre-menopausal receptor-positive or unknown status breast CA
47
clinical use of raloxifene
post-menopausal prevention of breast CA
48
clinical use of anastrozole
treatment of post-menopausal receptor-positive or unknown status breast CA
49
clinical use of leuprolide
hormone-sensitive prostate CA
50
clinical use of flutamide
prostate CA
51
clinical use of bevacizumab (Avastin)
metastatic colorectal CA | metastatic non-small cell lung CA
52
clinical use of imatinib (Gleevec)
malignant GIST tumors
53
clinical use of IL-2
metastatic melanoma | metastatic renal cell CA
54
clinical use of mitotane
unresectable/metastatic adrenocortical CA
55
clinical use of octreotide
pancreatic islet cell tumors | carcinoid syndrome
56
clinical use of cetuximab (Erbitux)
colorectal CA | head/neck CA
57
radio-resistant tumors
epithelial | sarcoma
58
radio-sensitive tumors
seminoma | lymphoma
59
mechanism of cytarabine
S-phase specific antimetabolite interferes with DNA/RNA polymerase
60
adverse effect of cytarabine
neutropenic enterocolitis

ABSITE (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions