Acetylcholine and Nicotine Flashcards
(12 cards)
1
Q
synthesis
A
Choline + Acetyl CoA via choline acetyltransferase (ChAT) = acetylcholine
2
Q
packaging of acetylcholine
A
VAChT (vesicular ACh transporter)
3
Q
____ degradation of acetylcholine by ____
A
enzymatic, acetylcholinesterases (AChEs)
4
Q
acetylcholinesterases
A
enzymes that break down ACh
5
Q
preganglionic neuron
A
soma is in spine or brain (CNS)
6
Q
ganglion
A
a collection of somas
7
Q
postganglionic neuron
A
soma is in ganglion and synapse/terminate onto target organ
8
Q
half life of nicotine
A
2 hours
9
Q
nicotine agonizes ____
A
nAChRs
10
Q
transient and/or low level nicotine is ____
A
agonizing
11
Q
prolonged and/or high level nicotine can cause ____ and block receptor ____
A
depolarization, inactivation
12
Q
why does nicotine cause upregulation
A
causes desensitization which increases number of receptors
