Hallucinogens Flashcards
(15 cards)
psilocybin is ____ into ____
dephosphorylated, psilocin
drugs that are “serotonin-like”
indoleamines
LSD activates the ____ branch of the ____ nervous system
sympathetic, autonomic
why is LSD tolerance lost relatively quickly (3-4 days)
receptor DOWNregulation
LSD and other indoleamines act on ____ receptors
serotonergic
what families of serotonin receptors do indoleamines and phenethylamines activate
2A and 2C
proposed mechanism of action of LSD
- activation of 5-HT2A receptors enhances glutamate-excitation of pyramidal neurons in layer 5 of PFC 2. Direct drug activation of PFC neurons - stronger connections with sensory areas and weaker connections with association areas
how is LSD absorbed
gastrointestinal
where is LSD distributed
1% of dose to brain, most goes to the liver
why does LSD have such a long duration of action
causes lid to form on serotonin receptor
what kind of relationship between serotonin receptor binding and effects from hallucinogens
positive, more serotonin receptor binding = more perceived drug effects
what happens if serotonin 1A receptor antagonist is given before LSD exposure?
no effect of drug
psychoplastogen
promote neural remodeling
how do hallucinogens promote neural remodeling:
increased complexity of arbors increases dendritic spines increased synapses
what is neural remodeling modulated by:
glutamatergic signals on NMDA and AMPA receptors
