Acetylcholine Esterase Inhibitors Flashcards Preview

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Flashcards in Acetylcholine Esterase Inhibitors Deck (36):
1

Drugs that augment Acetylcholine:

  • Sildenafil
  • Tadalfil and vardenafil
  • Rivastigmine and Galantamine

Mnemonic: ST(G)aRVe

2

Botulinum toxin

1. Acetylcholine Release Inhibitor

2. Rx of wrinkles

3. Botox injection will inhibit release of Acetylcholine --> paralysis of the muscle

3

Reversible Acetylcholine Esterase inhibitors (Indirect Agonists):

  •  Edrophonium
  •  Neostigmine and Pyridostigmine
  •  Physostigmine
  •  Donepezil

Mnemonic: Edro Stig-me and I’m Done

4

Edrophonium

1. Reversible Acetylcholinesterase inhibitor

2. Diagnosis of Myasthenia gravis

5

Physostigmine

1. Reversible Acetylcholinesterase inhibitor

2. Glaucoma; antidote in overdose of atropine

Note: tertiary amines (enter CNS)

6

Neostigmine

Pyridostigmine

1. Reversible Acetylcholinesterase inhibitor

2. Myasthenia gravis, ileus, urinary retention; Reversal of non- depolarizing NM blockers

Note: quaternary amines (No CNS)

7

Donepezil

Tacrine

1. Reversible Acetylcholinesterase inhibitor

2. Alzheimer's disease

8

Irreversible Acetylcholine esterase (Indirect Agonist) inhibitors:

  • Ecothiophate
  • Isoflurophate
  • Malathion and Parathion
  • Insecticides Toxicity (P450)

Mnemonic: Thion’s Fate

9

Ecothiophate

1. Irreversible Acetylcholinesterase inhibitor

2. Glaucoma

3. Increases outflow

Note: Organophosphates

10

Acetylcholine esterase inhibitors toxicity:

Parasympathetic stimulation:

  • Bradycardia
  • Bronchospasm
  • Diarrhea
  • Urinary incontinence
  • increased sweating, salivation and lacrimation
  • Muscle fasciculation and paralysis (Nm receptors)

Treatment of Toxicity: Atropine and Pralidoxime (2-PAM)

Note: Anticholinergics (Parasympatholytics) = Muscarinic receptors antagonists

Effects are opposite to Cholinergic, See below