Acetylcholine Esterase Inhibitors Flashcards Preview

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Flashcards in Acetylcholine Esterase Inhibitors Deck (10)
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1
Q

Drugs that augment Acetylcholine:

A
  • Sildenafil
  • Tadalfil and vardenafil
  • Rivastigmine and Galantamine

Mnemonic: ST(G)aRVe

2
Q

Botulinum toxin

A
  1. Acetylcholine Release Inhibitor
  2. Rx of wrinkles
  3. Botox injection will inhibit release of Acetylcholine –> paralysis of the muscle
3
Q

Reversible Acetylcholine Esterase inhibitors (Indirect Agonists):

A
  •  Edrophonium
  •  Neostigmine and Pyridostigmine
  •  Physostigmine
  •  Donepezil

Mnemonic: Edro Stig-me and I’m Done

4
Q

Edrophonium

A
  1. Reversible Acetylcholinesterase inhibitor
  2. Diagnosis of Myasthenia gravis
5
Q

Physostigmine

A
  1. Reversible Acetylcholinesterase inhibitor
  2. Glaucoma; antidote in overdose of atropine

Note: tertiary amines (enter CNS)

6
Q

Neostigmine

Pyridostigmine

A
  1. Reversible Acetylcholinesterase inhibitor
  2. Myasthenia gravis, ileus, urinary retention; Reversal of non- depolarizing NM blockers

Note: quaternary amines (No CNS)

7
Q

Donepezil

Tacrine

A
  1. Reversible Acetylcholinesterase inhibitor
  2. Alzheimer’s disease
8
Q

Irreversible Acetylcholine esterase (Indirect Agonist) inhibitors:

A
  • Ecothiophate
  • Isoflurophate
  • Malathion and Parathion
  • Insecticides Toxicity (P450)

Mnemonic: Thion’s Fate

9
Q

Ecothiophate

A
  1. Irreversible Acetylcholinesterase inhibitor
  2. Glaucoma
  3. Increases outflow

Note: Organophosphates

10
Q

Acetylcholine esterase inhibitors toxicity:

A

Parasympathetic stimulation:

  • Bradycardia
  • Bronchospasm
  • Diarrhea
  • Urinary incontinence
  • increased sweating, salivation and lacrimation
  • Muscle fasciculation and paralysis (Nm receptors)

Treatment of Toxicity: Atropine and Pralidoxime (2-PAM)

Note: Anticholinergics (Parasympatholytics) = Muscarinic receptors antagonists

Effects are opposite to Cholinergic, See below