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ANS Pharmacology > Adrenoceptor Agonists > Flashcards

Flashcards in Adrenoceptor Agonists Deck (17):
1

Methyldopa

1. Presynaptic alpha 2 agonists

2. Hypertension

2

Adrenoceptor Agonists:

Direct acting adrenoceptor agonist (Catecholamine):

  • Dopamine
  • Epinephrine
  • Norepinephrine
  • Isoproterenol
  • Dobutamine

 

Non-Catecholamine:

  • Clonidine
  • Oxymetazoline
  • Midodrine
  • Phenylephrine
  • Ritodrine
  • Albuterol
  • Apraclonidine

Mnemonic: COMP Right At Aua

 

Indirect Acting Adrenoceptor Agonists:

  • Amphetamine
  • Cocaine

 

Mixed Acting Adrenoceptor agonists:

  • Ephedrine
  • Pseudoephedrine

 

3

Phenylephrine

1. alpha 1 Agonists

2. Decongestant

Note: Causes Mydriasis without cycloplegia and Reflex bradycardia

4

Methoxamine

1. alpha 1 Agonists

2. PAT (paroxysmal atrial tachycardia)

5

Clonidine

1. alpha 2 Agonists

2. hypertension

3. decrease in BP

4. Rebound "overshoot" hypertension when discontinued

6

Alpha-methyl dopa

1. alpha 2 Agonists

3. prodrug

7

Dobutamine

1. B1>B2 Agonists

2. acute CHF

8

Isoproterenol

1. B1 = B2 Agonists

2. Bronchospasm

4. Flushing, arrhythmias

9

Metaproterenol

1. B2 Agonists 3. Bronchodilator

10

Albuterol

1. B2 Agonists 2. acute asthma

11

Salmetrol

1. B2 Agonists 2. Asthma prophylaxis 3. long acting bronchodilator

12

Terbutaline

1. B2 Agonists 3. Bronchodilator and Tocolytics

13

Ritodrine

1. B2 Agonists

2. Prevent premature labor

3. Tocolytics

14

Norepinephrine

1. Mixed alpha and beta agonists

3. alpha1, alpha 2, and B1.

B1: Increase cardiac contractility

Increased heart rate by B1 is overcome by alpha 1’s vasoconstriction --> reflex bradycardia

15

Epinephrine

1. Mixed alpha and beta agonists

2. Anaphylactic shock, cardiac arrest

3. alpha1, alpha2, B1, and B2.

In Low doses B are more sensitive. B1 increase contractility and heart rate. B2 --> vasodilation --> decrease TPR (No reflex).

In High doses alpha predominates. alpha1 --> vasoconstriction --> increase TPR, Reflex bradycardia

16

Tyramine

1. Indirect acting Adrenoceptor agonists

4. hypertensive crisis with MAO inhibitors

17

Dopamine

1. Indirect acting Adrenoceptor agonists

2.

3. Low dose (D1): Increase RBF and GFR.

Medium dose (D1, B1): increase CO.

Large dose (B1 and alpha 1): Vasoconstriction