Adrenoceptor Blockers Flashcards Preview

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Flashcards in Adrenoceptor Blockers Deck (8)
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1
Q

Adrenoceptor Antagonists

A

Alpha Adrenoceptor Antagonists

Non-Selective alpha blockers

  • Phenoxybenzamine
  • Phentolamine

Selective Alpha 1 blocker

  • Doxazosin
  • Alfuzosin
  • Tamsulosin

Beta Adrenoceptor Antagonists

Non-Selective B blockers

  • Propranolol
  • Timolol
  • Pindolol

Selective B1 Blockers

  • Atenolol
  • Metoprolol

Alpha and Beta Adrenoceptor antagonists

  • Carvedilol
  • Labetalol

Mnemonic: Phony People smoke DAT PTP in the AM CLearly

2
Q

Phentolamine

A
  1. Non-Selective alpha blockers

2.

  1. Competitive (reversible) alpha 1, alpha 2.

alpha 1 blockade leads to decrease TPR –> decreased BP, reflex tachycardia

3
Q

Phenoxybenzamine

A
  1. Non-Selective alpha blockers
  2. Short term use in pheochromocytoma
  3. noncompetitive (irreversible). makes covalent bond with alpha 1 receptors –> reflex tachycardia, miosis, inhibition of ejaculation
4
Q

Prazosin

Doxazosin

Terazosin

Tamsulosin

A
  1. Selective alpha 1 blockers
  2. Hypertension and BPH
  3. Elderly syncope

Note: Less reflex tackycardia.

Tamsulosin: Buzz word: Selective alpha 1 blocker only for BPH. reduced ejaculation

5
Q

Yohimbine

A
  1. Alpha 2 blockers
  2. Postural hypotension and impotence
6
Q

Mirtazapine

A
  1. Alpha 2 blockers
  2. Depression
7
Q

Propranolol

A
  1. NS Beta blocker
  2. Depression (cross BBB). Increase LDL and TGs
8
Q

Acebutolol

Metaprolol

Atenolol

A
  1. Cardio-selective B1 blockers

Note: Acebutolol (and Pindolol) are partial agonists (Intrinsic Sympathetic Activity) –> less bradycardia

Atenolol has no CNS entry (Nadolol too)