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Flashcards in Acids Bases & Buffers Deck (11)
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1

What is the law of mass action?

A + B C + D

The rate (Vf) of the forward reaction is proportional to the product of [A] and [B]
Vf = Kf[A][B]

The rate (Vr) of the reverse eaction is proportional to the product of [C] and [D]
Vr = Kr[C][D]

2

Define pH

measure of acidity/ basicity

log[H+] + log[OH] = -14
pH + pOH = 14

solution is neutral if pH =pOH = 7

3

Deinfe pKa

log { ([H+][A-])/[HA] }

measure of the strength of an acid or base

lower pKa = stronger acid
higher pKa = stronger base

4

Whats is the Henderson-Hasselbalch equation for any given weak acid or base?

Ka = [H+][A-]/ [HA]

5

What is normal blood pH?

arterial: 7.34-7.44
venous: 7.28-7.42

6

What is normal blood pCO2?

40

7

How do weak acids and bases work to buffer pH?

By resisting change in pH
- max capacity at 1:1
- speed bump

8

What is the pH range of maximal buffering capacity?

[A-]/[HA] = 0.1-10

9

What is the H-H equation for the bicarbonate system?

pH = 6.1 + log[HCO3-]/0.3pCO2

10

What are the clinical presentations of a change in CO2 levels?

respiratory alkalosis (decrease in CO2)
respiratory acidosis (increase in CO2)

11

What is the clinical presentation of a change in HCO3- levels?

metabolic alkakosis (increase bicarb)
metabolic acidosis (decreased bicarb)