ADENSOSINE

Question 1

CLASS

Answer 1

ENDOGENOUS NUCLEOSIDE, MISCELLANEOUS ANTIDYSRHYTHMIC

Question 2

DESCRIPTION

Answer 2

ADENOSINE SLOWS THE SVT BY DECREASING THE ELECTRICAL CONDUCTION THROUGH THE AV NODE WITHOUT CAUSING NEGATIVE INOTROPIC EFFECTS.
ALSO DIRECTLY CTS ON SINUS PACEMAKER CELLS AND VAGAL NERVE TERMINALS TO DECREASE CHRONOTROPIC ACTIVITY.

Question 3

ONSET AND DURATION

Answer 3

ONSET: IMMEDIATE
DURRATION: 10 SECONDS

Question 4

INDICATIONS

Answer 4

FIRST DRUG FOR MOST NARROW-COMPLEX PAOXYSMAL SVT AND DYSRHYTHMIAS ASSOCIATED WITH BYPASS TRACTS.
UNDIFFERENTIATED REGULAR STABLE WIDE- COMPLEX TACHYCARDIA

Question 5

CONTRAINDICATIONS

Answer 5

DRUG INDUCES TACHYCARDIA
2ND OR 3RD DEGREE AV BLOCK
HYPERSENSITIVITY
A-FLUTTER, A-FIB VT,
WPW WITH A-FIB OR A-FLUTTER

Question 6

ADVERSE REACTIONS

Answer 6

FACIAL FLUSHING, LIGHT HEADEDNESS ,PARESTHESIAS, HEADACHE, DIAPHORESIS, PALPATATIONS, CHEST PAIN, FLUSHING, HYPOTENSION, SOB, TRANISET PERIOD OF SINUS BRADYCARDIA, NAUSEA.

Question 7

DRUG INTERACTIONS

Answer 7

-METHYLXANTHINES (CAFFEINE) ANTAGONIZE THE ACTION OF ADENOSINE
-DIPYRIDAMOLE POTENTIALTES THE EFFECT OF ADENOSINE; REDUCTION DOSE MAY BE NEEDED
CARBAMAZEPINE MAY POTENTIATE THE AV-NODAL BLOCKING EFFECT OF ADENSOSINE

Question 8

HOW ADENOSINE IS SUPPLIED

Answer 8

PARENTERAL FOR IV INJECTION
3MG/ML IN 2-ML AND 4 ML FLIP TOP VIALS

Question 9

DOSAGE AND ADMINISTRATION

Answer 9

-INITIAL DOSE: 6-MG IV BOLUS OVER 1-3 SECONDS FOLLOWED BY 20 -ML SALINE BOLUS THEN ELEVATE EXTREMITY.
- SECOND DOSE: 12 MG MAY BE GIVEN IN 1-2 MINUTES IF NEEDED.
-RAPID PUSH PLACE PT IN MILD REVERSE TRENDELENBURG POSITION

Question 10

SPECIAL CONSIDERATION

Answer 10

-PREGNANCY SAFTEY- CATEGORY C
-A BRIEF PERIOD OF ASYSTOLE ( UP TO 15 SECONDS) FOLLOWING CONVERSIONS FOLLOW BY SNR
-REDUCE INITIAL DOSE TO 3 MG IN PT RECEIVING DIPYRIDAMOLE OR CARBAMAZEPINE
- PT TAKING THEOPHYLLINE OR CAFFEINE MAY NEED A LARGER DOSE
- MAY PRODUCE BRONCHSPASM IN PT WITH ASTHMA AND BRONCHIOLPULMONARY DISEASE.