ADR Management

Question 1

Deutetrabenazine/Austedo

Answer 1

Pros-
FDA approved for TD

Cons-
Expensive
BID dosing if above 12 mg/day

Question 2

Benztropine/Cogentin

Answer 2

Pros-
Good for acute onset DIP
Sedating

Cons
May not work for long-standing DIP
May not work for generalized dystonias (give Artane instead)

Question 3

Artane/Trihexyphenidyl

Answer 3

Pros
Good for generalized dystonias
Good for DIP
well-tolerated in younger people
Sedating

Cons
Dose dependent incidence of ADRs