Other antidepressants

Question 1

Vilazodone/Viibryd

Answer 1

Pros:
treatment-resistant MDD
treatment-resistant anxiety
off label OCD

Good for people worried about sexual dysfunction
Good for people worried about weight gain
Good for mixed anxiety and depression

Cons:
Must take with food
GI- N/V, diarrhea
CNS- insomnia, dizziness

Question 2

Vortioxetine/Trintellix

Answer 2

Pros:
Low on sexual side effects
Treatment-resistant MDD
Off-label treatment-resistant GAD
Depression with cognitive symptoms
Older adults with depression

Cons:
No generic
GI side effects- N/V/constipation
Can still cause sexual ADRs (rarer)

Question 3

Mirtazapine/Remeron

Answer 3

Pros
Good for depression and sleep
Increases appetite
Safe for combination use- California Rocket Fuel with venlafaxine or desvenlafaxine
Good for people with comorbid anxiety

Cons
Can gain weight
Need to taper to avoid withdrawal

Question 4

Bupropion/Wellbutrin

Answer 4

PROS
In SR form, good for meth abuse and smoking cessation
Less likely to induce mania than SSRI
Off label ADHD
Depression
Low on sexual ADRs
Helps weight loss

Cons
Makes people more anxious
Contraindicated in anorexia and bulimia nervosa
Can cause constipation and hair loss