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Flashcards in Adrenal Deck (16):
0

Catecholamines

Chromaffin cells
Epinephrine (adrenaline) norepinephrine and dopamine
Derived from amino acid tyrosine

1

Zona glomerulosa

Mineralocorticoid

2

Zona fasciculata

Glucocorticoid

3

Zona reticularis

Androgens

4

What does aldosterone do?

Increases sodium absorption in distal tubule in exchange for H+ or K+

5

How are glucocorticoids transported?

1. 83% bound to cortisol binding globulin
2. 17% bound to albumin

6

Metabolic actions of glucocorticoids

1. Increase gluconeogensis and glycolysis when fasting
2. Increase glycogen storage when feeding
3. Increase lipolysis
4. Increase protein catabolism

7

Glucocorticoids action on CNS

1. Increase appetite
2. Increase psychological disturbances
3. Role in coping with stress

8

Glucocorticoids action on bones

1. Increase bone resorption
2. Decrease bone matrix
3. #
4. AVN
5. Growth retardation

9

Glucocorticoid action on stomach

Increase risk of peptic ulcer

10

Glucocorticoids action on immune system

1. Anti - inflamm
2. Immunosuppressive
3. Inhibit fibroblasts - thin skin and brushing

11

Glucocorticoid effects of CVS

1. Vasoconstriction
2. Increase myocardial contractility
3. Decrease capillary permeability
4. Increase blood volume

12

Half life of glucocorticoids

90min

13

Stimulants of adrenal medulla

1. Fear
2. Stress
3. Hypoglycaemia
4. Anoxia
5. Pain
6. Haemorrhage

14

Noradrenaline

Alfa1 receptors - smooth.m
1. Vasoconstriction
2. Increase sweating
3. Increase sphincter tone
Alfa2 receptors - smooth.m
Vasoconstriction
Alfa2 receptors -fat
Decrease insulin secretion
Afla2 receptors - platelets
Increase sweating
Decrease GI motility
Beta1 receptors - cardiac tissue
Increase myocardial contractility

15

Adrenaline

Beta2 receptors - blood vessels
Vasodilation
Beta2 receptors - bronchioles
Increase glucagon
Bronchial dilatation
Beta3 receptors - fat
Lipolysis