Adrenergic Antagonists Flashcards Preview

RENAL II Exam 1 > Adrenergic Antagonists > Flashcards

Flashcards in Adrenergic Antagonists Deck (39):
1

phenoxybenzamine

alpha1 and alpha2 antagonist
-covalent binding

a1>a2

t1/2 - 24 hours

vasodilation and tachycardia

2

pheochromocytoma

tumor of adrenal medulla releasing NE and E

3

Tx for pheochromocytoma

pre-op management - phenoxybenzamine and beta blocker

4

phentolamine

alpha1 and alpha 2 antagonist

increases HCl in stomach

decreased BP leads to reflex tachycardia

stimulate GI motility and release of HCl

5

acute hypertensive emergency

phentolamine

accompany surgical manipulation of pheochromocytoma

BP maintenance

6

tolazoline

alpha1 and alpha2 antagonist

treat persistant vasoconstriction and HTN of newborn

7

yohimbine

selective alpha2 and 5-HT antagonist

claim - improve male sexual function

8

haloperidol

alpha1 and dopamine antagonist

9

chlorpromazine

alpha1 and dopamine antagonist

10

ergot alkaloids

in rye fungus

ingestion - gangrene, convulsions, spontaneous abortions

alpha antagonist

11

ergotamine

Tx for migraine headaches

alpha antagonist

12

prazosin

alpha1 >>>>alpha2 antagonist

selective alpha1 antagonist

decreased reflex tachycardia - bc leaves the alpha2 inhibition on NE release from nerve endings

13

terazosin

alpha1 selective antagonist

Tx of HTN and BPH

14

doxazosin

alpha1 selective antagonist

Tx of HTN and BPH

15

tamulosin

selective alpha1A antagonist

Tx of BPH
-with less reflex tachycardia

16

benign prostatic hypertrophy

Tx is reversal of smooth muscle contraction in enlarged prostate and bladder base

use alpha1 selective antagonist

17

propanolol

beta1 and beta2 antagonist

lipid soluble

decrease HR and CO

acute vasodilation
chronic decrease in TPR

blocks bronchodilation

blocks lipolysis and glycogenolysis

18

high dose propanolol

local anesthetic like membrane stabilizing effect

19

contraindication for propanolol

asthmatic

don't want the beta2 antagonist effect of propanolol

20

Tx of pheochromocytoma

propanolol and alpha antagonist

21

Tx of angina pectoris

propanolol

22

Tx of HTN

propanolol

23

Tx for stage fright

propanolol

24

after myocardial infarction

beta antagonist
ex. propanolol

shown to decrease arrhythmias and recurrent ischemia

25

use propanolol with caution

insulin dependent diabetics
-especially pancreatectomized

26

sudden withdrawal of propanolol

angina attack
rebound HTN
MI

**withdraw slowly by reducing disage

27

contraindications for propanolol

heart failure, cardiogenic shock, 2nd or 3rd degree AV block

asthma

28

nadolol

beta antagonists

longer acting than propanolol

Tx for angina and HTN

once a day dosage

29

timolol

beta antagonist

5-10x more potent than propanolol

Tx of HTN and glaucoma


30


timolol maleate

ophthalmic solution

-reduces aqueous humor prodiction in glaucoma

31

metoprolol

selective beta1 antagonist

Tx for HTN

widely used**

32

atenolol

beta1 antagonist

lessens risk of bronchospasm

33

labetalol

alpha1 and beta antagonist

Tx for HTN and pheochromocytoma

34

carvedilol

beta antagonist
also some alpha1 antagonist

reduce mortality in patients with CHF

35

pindolol

partial beta2 agonist activity

HTN and angina Tx

36

acebutolol

beta1 partial agonist

HTN and dysrhythmias

37

betaxolol

beta1 selective antagonist

glaucoma and HTN Tx

38

esmolol

short acting beta1 antagonist

clinical use - prophylactic for perioperative tachycardia and HTN, as well as electroconvulsive therapy

39

Tx for pheochromocytoma

phentolamine and phenoxybenzamine

beta antagonist used after alpha blockade established