Sympathomimetics Flashcards Preview

RENAL II Exam 1 > Sympathomimetics > Flashcards

Flashcards in Sympathomimetics Deck (68):
1

constriction of blood vessels

alpha 1
lesser extent alpha 2

2

mydriasis

alpha 1
-iris radial muscle
-dilation of pupil

3

contraction of spleen

alpha 1

4

contraction of uterus

alpha 1

5

constrict sphincter of bladder

alpha 1

6

liver glycogenolysis

alpha 1

7

ejaculation

alpha 1

8

insulin release inhibition

alpha 2

9

relax intestinal smooth muscle

alpha 2

10

increased contraction and rate of heart

beta 1

11

increased renin release

beta 1

12

relax bronchioles

beta 2

13

relax uterus

beta 2

14

relax vascular smooth m in certain blood vessels - skeletal m, coronaries, mesenteric

beta 2

15

glycogenolysis

beta 2

16

lipolysis

beta 1

17

insulin release stimulation

beta 2

18

relax detrusor muscle

beta 2

to store urine

voiding - contracts

19

relax intestinal smooth m

beta 2

20

structure of catecholamines

catechol and ethylamine with different side groups

21

tyramine

catecholamine releasing agent

blocked by cocaine

22

action of beta receptors

stimulate adenylyl cyclase

23

action of alpha receptors

inhibit adenylyl cyclase

24

action of epinephrine

increase heart rate and contractility

low dose - beta 2 skeletal m vessel relaxation
high dose - alpha 1 skeletal m vessel constriction

25

epinephrine on pancreas

alpha 2 > beta 2
-block release of insulin

26

prolonged local anesthetics

when mixed with epinephrine

27

anaphylactic shock

treat with IM injection of epinephrine

efficacy on alpha 1 and beta 2 receptors

28

contraindications for epinephrine

HTN
shock
hyperthyroid
angina pectoris
asthmatics with degenerative heart disease

29

vasculature alpha vs. beta

beta 2 - relax
alpha 1 - constrict

30

beta receptor antagonists in eye

decrease aqueous humor production

31

alpha receptor agonists in eye

mydriasis
also - increase aqueous humor outflow

32

CV and epinephrine

beta1, beta2, alpha effects

increased systolic (beta1)

decreased TPR and decreased diastolic (beta2 skeletal m. dilation overcomes alpha1 constriction)


33

CV and norepinephrine

beta1, alpha effects

no beta2**

increased TPR and diastolic (no beta2 on skeletal m. dilation, only alpha1 constriction effects)

increased systolic BP and MAP

stimulant on rate, but overcome by reflex baroreceptor vagal output

34

CV and isoproterenol

beta1, beta 2 effects

no alpha**

increased HR and force of contraction (beta1)

decreased TPR (beta2 in skeletal m vasodilation)

increased systolic
decreased diastolic

35

dopamine

beta1 agonist
D1 agonist

high dose - alpha1 agonist
-will override dopaminergic effects

36

effect of dopamine

increased HR and contractility - beta1

increased blood flow in renal, coronary, splanchnic - D1

37

higher dose of dopamine

alpha1 receptor activation
-overcomes vasodilatory effects

38

femoldopam

D1 agonist

Tx for hypertension

39

bromocroptine

D2 agonist

Tx for parkinsons or prolactinemia

40

dobutamine

beta1 agonist

weak increase in contractility and HR

41

clinical use of dobutamine

increased CO in patients with cardiogenic shock with decreased occurence of arrythmia

42

phenylephrine

alpha-1 agonists

vascular constriction
-reflex bradycardia
-can be blocked with atropine

43

methoxamine

alpha 1 agonist

similar to phenylephrine

44

midodrine

alpha 1 agonist

Tx for disabling orthostatic hyoptension

45

beta 2 agonists

10x greater selectivity for beta2 than beta1

so beta1 can be stimulated at high dose

46

albuterol

beta 2 agonist

for bronchial asthma

47

salmeterol

beta 2 agonist

long lasting

nighttime asthma

48

formoterol

beta 2 agonist

same as salmeterol

long acting

49

metaproterenol

beta 2 agonist

relax bronchial smooth muscle

side effects: nervous, weak, palpitations, N/V

50

terbutaline

beta 2 agonist

used orally and as aerosol

51

ritodrine

beta 2 agonist

for delayed delivery

52

amphetamines

release NE from adrenergic nerve ending AND inhibit NE reuptake

CNS stimulant

53

adderall

amphetamine
for ADHD

54

dexedrine

amphetamine

55

benzedrine

amphetamine

56

Tx for narcolepsy

amphetamine

57

Tx for obesity

amphetamine

58

Tx for ADHD

amphetamine

59

amphetamine poisoning

weak bases

acidification of urine will decrease reabsorption

60

mixed action

ephedrine

61

ephedrine

beta agonist AND indirect NE release

62

pseudoephedrine

OTC cough and cold
-now illegal bc can be used to make methamphetamine

63

nasal decongestants

alpha 1 vasoconstriction

64

naphazoline

nasal decongestant

65

tetrahydrozoline

nasal decongestant

66

xylometazoline

nasal decongestant

67

oxymetazoline

nasal decongestant

68

hydroxyamphetamine

similar to ephedrine
-but decreased CNS activity due to more polarity