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Pharmacology: Autonomic Nervous System Drugs > Adrenergic Drugs > Flashcards

Flashcards in Adrenergic Drugs Deck (16):
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adrenergic agonists

drugs that stimulate and mimic the actions of the sympathetic nervous system; also called sympathomimetics

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adrenergic receptors

receptor sites for the sympathetic neurotransmitters norepinephrine and epinephrine

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alpha-adrenergic receptors

a class of adrenergic receptors that are further subdivided into alpha1- and alpha2-adrenergic receptors

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autonomic functions

bodily functions that are involuntary and result from the physiologic activity of the autonomic nervous system; the functions often occur in pairs of opposing actions between the sympathetic and parasympathetic divisions of the autonomic nervous system

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autonomic nervous system

a branch of the peripheral nervous system that controls autonomic bodily functions; it consists of the sympathetic nervous system and the parasympathetic nervous system

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beta-adrenergic receptors

receptors located on postsynaptic cells that are stimulated by specific autonomic nerve fibers; beta1-adrenergic receptors are located primarily in the heart, whereas beta2-adrenergic receptors are located in the smooth muscle fibers of the bronchioles, arterioles, and visceral organs

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catecholamines

substances that can produce a sympathomimetic response; they are either endogenous catecholamines (e.g. epinephrine, norepinephrine, and dopamine) or synthetic catecholamine drugs (e.g. dobutamine)

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dopaminergic receptors

a third type of adrenergic receptor (in addition to alpha-adrenergic and beta-adrenergic receptors) located in various tissues and organs and activated by the binding of the neurotransmitter dopamine, which can be either endogenous or a synthetic drug form

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mydriasis

pupillary dilation, whether natural (physiologic) or drug induced

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ophthalmics

drugs that are used in the eyes

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positive chronotropic effect

an increase in heart rate

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positive dromotropic effect

an increase in the conduction of cardiac electrical impulses through the atrioventricular node, which results in the transfer of nerve action potentials from the atria to the ventricles; this is ultimately leads to a systolic heartbeat (ventricular contractions)

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positive inotropic effect

an increase in the force of contraction of the heart muscle (myocardium)

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sympathomimetics

drugs used therapeutically that mimic the catecholamines epinephrine, norepinephrine, and dopamine; also called adrenergic agonists

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synaptic cleft

the space between two adjacent nerve cell membranes or between a nerve cell membrane and an effector organ cell membrane (also called synapse)

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adrenergic drugs

dobutamine [Dobutrex], dopamine [Intropin], epinephrine [Adrenalin], fenoldopam, midodrine, norepinephrine, phenylephrine